Rabbit TIMM8B Polyclonal Antibody | anti-TIMM8B antibody

TIMM8B Polyclonal Conjugated Antibody

Cat. Num. AAA9440762

• Gene Names: TIMM8B; DDP2; TIM8B
• Reactivity: Human, Mouse, Rat
• Applications: Most Applications
• Purity: Affinity purification
• Synonyms: TIMM8B; Polyclonal Antibody; TIMM8B Polyclonal Conjugated Antibody; TIMM8B Conjugated Antibody; DDP2; TIM8B; translocase of inner mitochondrial membrane 8 homolog B; anti-TIMM8B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-TIMM8B antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Recombinant fusion protein of human TIMM8B (NP_036591.2).
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-TIMM8B antibody

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.

NCBI and Uniprot Product Information

• NCBI GI #: 256773260
• NCBI GeneID: 26521
• NCBI Accession #: NP_036591.2
• NCBI GenBank Nucleotide #: NM_012459.2
• UniProt Accession #: Q9Y5J9; Q3KQS9; Q9UN04; B0YJA5
• Molecular Weight: 9,344 Da
• NCBI Official Full Name: mitochondrial import inner membrane translocase subunit Tim8 B
• NCBI Official Synonym Full Names: translocase of inner mitochondrial membrane 8 homolog B (yeast)
• NCBI Official Symbol: TIMM8B
• NCBI Official Synonym Symbols: DDP2; TIM8B
• NCBI Protein Information: mitochondrial import inner membrane translocase subunit Tim8 B; DDP-like protein; deafness dystonia protein 2
• UniProt Protein Name: Mitochondrial import inner membrane translocase subunit Tim8 B
• Protein Family: Mitochondrial import inner membrane translocase
• UniProt Gene Name: TIMM8B
• UniProt Synonym Gene Names: DDP2; DDPL; TIM8B
• UniProt Entry Name: TIM8B_HUMAN

NCBI Description

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Uniprot Description

Function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space

By similarity.

Subunit structure: Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22

By similarity.

Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side

By similarity.

Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. Ref.2

Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane

By similarity.

Sequence similarities: Belongs to the small Tim family.