Rabbit anti-Human TIMM8B Polyclonal Antibody | anti-TIMM8B antibody

TIMM8B Antibody

Cat. Num. AAA1496524

• Gene Names: TIMM8B; DDP2; TIM8B
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G Purified
• Synonyms: TIMM8B; Polyclonal Antibody; TIMM8B Antibody; Mitochondrial import inner membrane translocase subunit Tim8 B; DDP2; DDPL; TIM8B; DDP-like protein; Deafness dystonia protein 2; anti-TIMM8B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 98

• Applicable Applications for anti-TIMM8B antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Mitochondrial import inner membrane translocase subunit Tim8 B protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17055
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS1496524 at dilution of 1:100)

Related Product Information for anti-TIMM8B antibody

Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 256773260
• NCBI GeneID: 26521
• NCBI Accession #: NP_036591.2
• NCBI GenBank Nucleotide #: NM_012459.2
• UniProt Accession #: Q9Y5J9; Q3KQS9; Q9UN04; B0YJA5
• Molecular Weight: 9,344 Da
• NCBI Official Full Name: mitochondrial import inner membrane translocase subunit Tim8 B
• NCBI Official Synonym Full Names: translocase of inner mitochondrial membrane 8 homolog B (yeast)
• NCBI Official Symbol: TIMM8B
• NCBI Official Synonym Symbols: DDP2; TIM8B
• NCBI Protein Information: mitochondrial import inner membrane translocase subunit Tim8 B
• UniProt Protein Name: Mitochondrial import inner membrane translocase subunit Tim8 B
• Protein Family: Mitochondrial import inner membrane translocase
• UniProt Gene Name: TIMM8B
• UniProt Synonym Gene Names: DDP2; DDPL; TIM8B
• UniProt Entry Name: TIM8B_HUMAN

NCBI Description

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Uniprot Description

TIMM8B: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Belongs to the small Tim family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 11q23.1-q23.2

Cellular Component: extracellular space; mitochondrial inner membrane; mitochondrial intermembrane space protein transporter complex

Molecular Function: zinc ion binding

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion; sensory perception of sound