Rabbit anti-Human TIE1 / TIE Polyclonal Antibody | anti-TIE1 antibody

Rabbit Polyclonal (IgG) to Human TIE1 / TIE

Cat. Num. AAA242854

• Gene Names: TIE1; TIE; JTK14
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: TIE1 / TIE; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human TIE1 / TIE; Anti-TIE1 / TIE Antibody (C-Terminus) IHC-plus; TIE1; JTK14; TIE; Tie-1; Human TIE1; anti-TIE1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 10 mM PBS, pH 7.4, BSA, sodium azide.
• Sequence Length: 1138

• Applicable Applications for anti-TIE1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (1:50)
• Target Species: Human
• Immunogen Description: Synthetic peptide corresponding to C-terminal of human Tie-1.
• Immunogen Type: Synthetic peptide
• Immunogen: TIE1 / TIE antibody was raised against synthetic peptide corresponding to C-terminal of human Tie-1.
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at 2 degree C to 8 degree C degrees. Do not freeze.

Immunohistochemistry (IHC)

(Anti-TIE1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)

Related Product Information for anti-TIE1 antibody

TIE1 is a receptor that is implicated in vessel maturation and angiogenesis. TIE1 contains immunoglobulin-like loops and epidermal growth factor (EGF) homology domains.

Product Categories/Family for anti-TIE1 antibody

Family: Protein Kinase; Subfamily: Tie/Tek

NCBI and Uniprot Product Information

• NCBI GI #: 4885631
• NCBI GeneID: 7075
• NCBI Accession #: NP_005415.1
• NCBI GenBank Nucleotide #: NM_005424.4
• UniProt Accession #: P35590; B5A949; B5A950
• Molecular Weight: 34,138 Da
• NCBI Official Full Name: tyrosine-protein kinase receptor Tie-1 isoform 1
• NCBI Official Synonym Full Names: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
• NCBI Official Symbol: TIE1
• NCBI Official Synonym Symbols: TIE; JTK14
• NCBI Protein Information: tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
• UniProt Protein Name: Tyrosine-protein kinase receptor Tie-1
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: TIE1
• UniProt Synonym Gene Names: TIE
• UniProt Entry Name: TIE1_HUMAN

NCBI Description

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

TIE1: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.

Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; TK group; Tie family

Chromosomal Location of Human Ortholog: 1p34-p33

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: negative regulation of angiogenesis; response to retinoic acid; peptidyl-tyrosine phosphorylation; in utero embryonic development; mesoderm development; angiogenesis; signal transduction; vasculogenesis; negative regulation of cell migration; plasma membrane fusion