Rabbit anti-Human TICAM2 Polyclonal Antibody | anti-TICAM2 antibody

TICAM2, NT (TICAM2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein) (MaxL

Cat. Num. AAA6355522

• Gene Names: TMED7-TICAM2; TAG
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TICAM2; Polyclonal Antibody; NT (TICAM2; TIRAP3; TIRP; TRAM; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein) (MaxL; Toll/interleukin-1 receptor domain-containing protein; anti-TICAM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-TICAM2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TICAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human TICAM2.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TICAM2 antibody

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).

Product Categories/Family for anti-TICAM2 antibody

Antibodies; Interleukin

References

Lysakova-Devine, T., et al. J. Immunol. 185(7):4261-4271(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Palsson-McDermott, E.M., et al. Nat. Immunol. 10(6):579-586(2009). Hawn, T.R., et al. PLoS ONE 4 (6), E5990 (2009): Nakajima, T., et al. Immunogenetics 60(12):727-735(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 256985102
• NCBI GeneID: 100302736
• NCBI Accession #: NP_001157941.1; NP_067681.1
• NCBI GenBank Nucleotide #: NM_001164469.2
• UniProt Accession #: Q86XR7; B3Y698
• Molecular Weight: 26,916 Da
• NCBI Official Full Name: TRAM adaptor with GOLD domain isoform 2
• NCBI Official Synonym Full Names: TMED7-TICAM2 readthrough
• NCBI Official Symbol: TMED7-TICAM2
• NCBI Official Synonym Symbols: TAG
• NCBI Protein Information: TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript
• UniProt Protein Name: TIR domain-containing adapter molecule 2
• Protein Family: TIR domain-containing adapter molecule
• UniProt Gene Name: TICAM2
• UniProt Synonym Gene Names: TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
• UniProt Entry Name: TCAM2_HUMAN

Uniprot Description

TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; early endosome membrane; endoplasmic reticulum; late endosome membrane; early endosome; late endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway