Rabbit anti-Human TICAM2 Polyclonal Antibody | anti-TICAM2 antibody

TICAM2, NT (TICAM2, TIRAP3, TIRP, TRAM, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein) (Biot

Cat. Num. AAA6355516

• Gene Names: TMED7-TICAM2; TAG
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TICAM2; Polyclonal Antibody; NT (TICAM2; TIRAP3; TIRP; TRAM; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein) (Biot; Toll/interleukin-1 receptor domain-containing protein; anti-TICAM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TICAM2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TICAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human TICAM2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TICAM2 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TICAM2 antibody detected the TICAM2 protein (arrow).)

Related Product Information for anti-TICAM2 antibody

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).

Product Categories/Family for anti-TICAM2 antibody

Antibodies; Interleukin

References

Lysakova-Devine, T., et al. J. Immunol. 185(7):4261-4271(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Palsson-McDermott, E.M., et al. Nat. Immunol. 10(6):579-586(2009). Hawn, T.R., et al. PLoS ONE 4 (6), E5990 (2009): Nakajima, T., et al. Immunogenetics 60(12):727-735(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 256985102
• NCBI GeneID: 100302736
• NCBI Accession #: NP_001157941.1; NP_067681.1
• NCBI GenBank Nucleotide #: NM_001164469.2
• UniProt Accession #: Q86XR7; B3Y698
• Molecular Weight: 26,916 Da
• NCBI Official Full Name: TRAM adaptor with GOLD domain isoform 2
• NCBI Official Synonym Full Names: TMED7-TICAM2 readthrough
• NCBI Official Symbol: TMED7-TICAM2
• NCBI Official Synonym Symbols: TAG
• NCBI Protein Information: TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript
• UniProt Protein Name: TIR domain-containing adapter molecule 2
• Protein Family: TIR domain-containing adapter molecule
• UniProt Gene Name: TICAM2
• UniProt Synonym Gene Names: TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
• UniProt Entry Name: TCAM2_HUMAN

Uniprot Description

TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: Golgi apparatus; early endosome membrane; endoplasmic reticulum; late endosome membrane; early endosome; late endosome; plasma membrane; endosome membrane

Molecular Function: signal transducer activity; phospholipid binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway