Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human spleen tissue using MBS7045574 at dilution of 1:100)
Rabbit anti-Human TIAM1 Polyclonal Antibody | anti-TIAM1 antibody
TIAM1 Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human spleen tissue using MBS7045574 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human spleen tissue using MBS7045574 at dilution of 1:100)
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells using MBS7045574 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells using MBS7045574 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
Uniprot Description
TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes.
Protein type: GEFs; Oncoprotein; Motility/polarity/chemotaxis; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction
Research Articles on TIAM1
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Product Notes
The TIAM1 tiam1 (Catalog #AAA7045574) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIAM1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TIAM1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the TIAM1 tiam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIAM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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