Rabbit TGM5 Polyclonal Antibody | anti-TGM5 antibody

TGM5 Antibody

Cat. Num. AAA9409272

• Gene Names: TGM5; TGX; PSS2; TGM6; TGMX; TGASE5; TGASEX
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TGM5; Polyclonal Antibody; TGM5 Antibody; Transglutaminase 5; protein-glutamine gamma-glutamyltransferase 5; TGase-5; TGase X; TGMX; TGX; anti-TGM5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: TGM5 antibody is predicted to not cross-react with other TGase protein family members. Multiple isoforms of TGM5 are known to exist.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 720

• Applicable Applications for anti-TGM5 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 19 amino acid peptide near the carboxy terminus of human TGM5.
• Target Name: TGM5
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TGM5 in rat heart tissue lysate with TGM5 antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-TGM5 antibody

Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM5 belongs to the transglutaminase superfamily and catalyzes the cross-linking of proteins between glutamine and lysine residues, often resulting in stabilization of protein assemblies. TGM5 is also expressed in the human hair follicle. Defects in TGM5 are associated with acral peeling skin syndrome.

Product Categories/Family for anti-TGM5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 94981556
• NCBI GeneID: 9333
• NCBI Accession #: NP_963925
• NCBI GenBank Nucleotide #: NM_201631.3
• Molecular Weight: 71,919 Da
• NCBI Official Full Name: protein-glutamine gamma-glutamyltransferase 5 isoform 1
• NCBI Official Synonym Full Names: transglutaminase 5
• NCBI Official Symbol: TGM5
• NCBI Official Synonym Symbols: TGX; PSS2; TGM6; TGMX; TGASE5; TGASEX
• NCBI Protein Information: protein-glutamine gamma-glutamyltransferase 5
• UniProt Protein Name: Protein-glutamine gamma-glutamyltransferase 5
• Protein Family: Protein-glutamine gamma-glutamyltransferase
• UniProt Gene Name: TGM5
• UniProt Synonym Gene Names: TGMX; TG(X); TGX; TGase X; TGase-5
• UniProt Entry Name: TGM5_HUMAN

NCBI Description

This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]

Uniprot Description

TGM5: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. Defects in TGM5 are a cause of peeling skin syndrome type A (APSS). A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.3.2.13

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: cytoplasm

Molecular Function: protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: epidermis development; protein modification process; peptide cross-linking

Disease: Peeling Skin Syndrome 2