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Rabbit anti-Mouse TGF beta 2 Polyclonal Antibody | anti-TGFB2 antibody

Anti-TGF beta 2 Antibody, Rabbit Polyclonal

Gene Names
Tgfb2; Tgfb-2; BB105277; Tgf-beta2
Reactivity
Mouse
Applications
ELISA
Purity
Protein A
Synonyms
TGF beta 2; Polyclonal Antibody; Anti-TGF beta 2 Antibody; Rabbit Polyclonal; TGF-beta 2 Antibody; Rabbit PAb; transforming growth factor beta 2; Anti-BB105277 Antibody; Anti-TGF-beta 2 Antibody; Anti-Tgf-beta2 Antibody; Anti-Tgfb-2 Antibody; Anti-TGFB2 Antibody; anti-TGFB2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse TGF-beta 2
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-TGFB2 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000-1:2000
Immunogen
Recombinant Mouse TGF-beta 2 Protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse TGF-beta 2 (rM TGF-beta 2). Total IgG was purified by Protein A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-TGFB2 antibody
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. Besides, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.
Product Categories/Family for anti-TGFB2 antibody
References
Schlingensiepen KH, et al. (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev. 17(1-2): 129-39.Ghatpande SK, et al. (2010) Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. Dev Growth Differ. 52(5): 433-55.Noguchi A, et al. (2010) Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains. Int J Neurosci. 120(3): 168-75.Li J, et al. (2011) Comparative effects of TGF-_2/Smad2 and TGF-_2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line. Exp Eye Res. 92(3): 173-9.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
47,589 Da
NCBI Official Full Name
transforming growth factor beta-2
NCBI Official Synonym Full Names
transforming growth factor, beta 2
NCBI Official Symbol
Tgfb2
NCBI Official Synonym Symbols
Tgfb-2; BB105277; Tgf-beta2
NCBI Protein Information
transforming growth factor beta-2; TGF-beta-2
UniProt Protein Name
Transforming growth factor beta-2
UniProt Gene Name
Tgfb2
UniProt Synonym Gene Names
TGF-beta-2; LAP
UniProt Entry Name
TGFB2_MOUSE

Uniprot Description

TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; axon; cytoplasm; extracellular region; basement membrane; trans-Golgi network; endosome; secretory granule

Molecular Function: protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; beta-amyloid binding; punt binding; cytokine activity; protein N-terminus binding; transforming growth factor beta receptor binding; receptor binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart morphogenesis; extracellular matrix organization and biogenesis; collagen fibril organization; catagen; positive regulation of apoptosis; heart development; SMAD protein nuclear translocation; dopamine biosynthetic process; protein amino acid phosphorylation; regulation of apoptosis; hair follicle development; transforming growth factor beta receptor signaling pathway; somatic stem cell division; cell cycle arrest; cell growth; cartilage condensation; response to drug; negative regulation of keratinocyte differentiation; negative regulation of immune response; neuron fate commitment; positive regulation of cell cycle; positive regulation of catagen; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; cardioblast differentiation; positive regulation of protein secretion; response to estrogen stimulus; positive regulation of cell division; regulation of MAPKKK cascade; activation of protein kinase activity; neuron development; response to progesterone stimulus; positive regulation of heart contraction; negative regulation of apoptosis; cell death; axon guidance; wound healing; cell morphogenesis; cardiac muscle cell proliferation; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of neuron apoptosis; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of cell proliferation; embryonic neurocranium morphogenesis; hemopoiesis; positive regulation of integrin biosynthetic process; skeletal development; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; blood vessel development; cell migration; regulation of transforming growth factor-beta2 production; hair follicle morphogenesis; positive regulation of cell adhesion mediated by integrin; glial cell migration; regulation of cell proliferation; eye development; positive regulation of cardioblast differentiation; response to hypoxia; epithelial to mesenchymal transition; blood vessel remodeling; negative regulation of cell growth; positive regulation of cell migration; growth

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Product Notes

The TGFB2 tgfb2 (Catalog #AAA8111106) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TGF beta 2 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TGF beta 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000. Researchers should empirically determine the suitability of the TGFB2 tgfb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGF beta 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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