Rabbit anti-Human TESK2 Polyclonal Antibody | anti-TESK2 antibody

TESK2 Antibody

Cat. Num. AAA7046575

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: TESK2; Polyclonal Antibody; TESK2 Antibody; Dual specificity testis-specific protein kinase 2; Testicular protein kinase 2; anti-TESK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 488

• Applicable Applications for anti-TESK2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Dual specificity testis-specific protein kinase 2 protein (C-270AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82372 / sc-82374
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue using MBS7046575 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7046575 at dilution 1:100)

Related Product Information for anti-TESK2 antibody

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 1002883851
• NCBI GeneID: 10420
• NCBI Accession #: NP_001307729.1
• NCBI GenBank Nucleotide #: NM_001320800.1
• UniProt Accession #: Q96S53; Q5T422; Q5T423; Q8N520; Q9Y3Q6
• Molecular Weight: 60,332 Da
• NCBI Official Full Name: dual specificity testis-specific protein kinase 2 isoform 2
• NCBI Official Synonym Full Names: testis-specific kinase 2
• NCBI Official Symbol: TESK2
• NCBI Protein Information: dual specificity testis-specific protein kinase 2
• UniProt Protein Name: Dual specificity testis-specific protein kinase 2
• Protein Family: Dual specificity testis-specific protein kinase
• UniProt Gene Name: TESK2
• UniProt Entry Name: TESK2_HUMAN

NCBI Description

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

TESK2: a TKL kinase of the LISK family. Predominantly expressed in testis and prostate. The developmental expression pattern in the testis suggests an important role in meitoic stages and/or early stages of spermiogenesis. Three alternatively spliced isoforms have been described.

Protein type: EC 2.7.12.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; LISK family; TESK subfamily

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis; focal adhesion formation; protein amino acid phosphorylation; spermatogenesis