Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using TESC Antibody. The lane on the left was treated with blocking peptide.)
Rabbit TESC Polyclonal Antibody | anti-TESC antibody
TESC Antibody
Gene Names
TESC; TSC; CHP3
Reactivity
Human, Mouse, RatPredicted: Pig, Bovine, Horse, Rabbit, Dog
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TESC; Polyclonal Antibody; TESC Antibody; 1010001A17Rik; Calcineurin B homologous protein 3; CHP3; FLJ20607; MGC117906; OTTHUMP00000185561; OTTMUSP00000023573; TE 1; Tescalcin; TSC; anti-TESC antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Pig, Bovine, Horse, Rabbit, Dog
Predicted: Pig, Bovine, Horse, Rabbit, Dog
Clonality
Polyclonal
Isotype
IgG
Specificity
TESC Antibody detects endogenous levels of TESC.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
187
Applicable Applications for anti-TESC antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human TESC.
Tissue Specificity
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Plasma Membrane; Nucleus
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using TESC Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, using TESC Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Rat brain, using TESC Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Rat brain, using TESC Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-TESC antibody
Description: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Subunit Structure: Monomer. Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1 (via juxtamembrane region of the cytoplasmic C-terminus); the interaction enable an optimal Na+/H+ exchange activity.
Similarity: Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity). Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Subunit Structure: Monomer. Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1 (via juxtamembrane region of the cytoplasmic C-terminus); the interaction enable an optimal Na+/H+ exchange activity.
Similarity: Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity). Belongs to the calcineurin regulatory subunit family. CHP subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 25 kDa
Predicted: 25 kDa
Predicted: 25 kDa
NCBI Official Full Name
calcineurin B homologous protein 3 isoform 2
NCBI Official Synonym Full Names
tescalcin
NCBI Official Symbol
TESC
NCBI Official Synonym Symbols
TSC; CHP3
NCBI Protein Information
calcineurin B homologous protein 3
UniProt Protein Name
Calcineurin B homologous protein 3
Protein Family
UniProt Gene Name
TESC
UniProt Synonym Gene Names
CHP3; TSC
UniProt Entry Name
CHP3_HUMAN
Research Articles on TESC
Similar Products
Product Notes
The TESC tesc (Catalog #AAA9611520) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TESC Antibody reacts with Human, Mouse, Rat Predicted: Pig, Bovine, Horse, Rabbit, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's TESC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TESC tesc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TESC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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