Rabbit TDRKH Polyclonal Antibody | anti-TDRKH antibody

TDRKH Polyclonal Antibody

Cat. Num. AAA3011724

• Gene Names: TDRKH; TDRD2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TDRKH; Polyclonal Antibody; TDRKH Polyclonal Antibody; Tudor and KH domain-containing protein; Tudor domain-containing protein 2; TDRD2; anti-TDRKH antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TDRKH polyclonal antibody detects endogenous levels of TDRKH protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 561

• Applicable Applications for anti-TDRKH antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human TDRKH.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using TDRKH antibody.)

Related Product Information for anti-TDRKH antibody

TDRKH (tudor and KH domain-containing protein), also known as TDRD2 (tudor domain-containing protein 2), is a 561 amino acid protein that contains two KH domains and one tudor domain. TDRKH exists as two alternatively spliced isoforms and interacts with HIWI and HILI2. The gene that encodes TDRKH contains roughly 21, 310 bases and maps to human chromosome 1q21. With roughly 3, 000 genes that span about 260 million base pairs, chromosome 1 makes up approximately 8% of the human genome. There are also a large number of diseases associated with chromosome 1, notably, the rare aging disease Hutchinson-Gilford progeria which is associated with the LMNA gene that encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.

NCBI and Uniprot Product Information

• NCBI GI #: 332278122
• NCBI GeneID: 11022
• UniProt Accession #: Q9Y2W6
• Molecular Weight: ~ 72kDa
• NCBI Official Full Name: Tudor and KH domain-containing protein
• NCBI Official Synonym Full Names: tudor and KH domain containing
• NCBI Official Symbol: TDRKH
• NCBI Official Synonym Symbols: TDRD2
• NCBI Protein Information: tudor and KH domain-containing protein
• UniProt Protein Name: Tudor and KH domain-containing protein
• Protein Family: Tudor and KH domain-containing protein
• UniProt Gene Name: TDRKH
• UniProt Synonym Gene Names: TDRD2
• UniProt Entry Name: TDRKH_HUMAN

Uniprot Description

TDRKH: a protein containing one Tudor and two KH_1 domims. Tudor domains have been shown to interact with arginine-glycine-rich motifs in a methylarginine-dependent manner, and target methylated arginines physiologically. KH domains are RNA-binding domains found in a wide variety of nucleic acid-binding proteins. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: mitochondrion

Molecular Function: RNA binding

Biological Process: fertilization; DNA methylation during gametogenesis; RNA-mediated gene silencing; gene expression; spermatogenesis; cell differentiation; male meiosis