Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue?, using TDRKHspecific Antibody. The lane on the left was treated with blocking peptide.)
Rabbit TDRKH Polyclonal Antibody | anti-TDRKH antibody
TDRKH Specific Antibody
Gene Names
TDRKH; TDRD2
Reactivity
Human, Mouse, RatPredicted: Pig, Bovine, Horse, Sheep, Rabbit
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TDRKH; Polyclonal Antibody; TDRKH Specific Antibody; 2700091C21Rik; Putative RNA binding protein; RGD1311196; RP11-98D18.8; TDRD2; TDRD7; Tdrkh; TDRKH_HUMAN; Tudor and KH domain containing; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2; anti-TDRKH antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Pig, Bovine, Horse, Sheep, Rabbit
Predicted: Pig, Bovine, Horse, Sheep, Rabbit
Clonality
Polyclonal
Isotype
IgG
Specificity
TDRKHspecific Antibody detects endogenous levels of TDRKHspecific.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
561
Applicable Applications for anti-TDRKH antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human TDRKHspecific.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Mitochondrion
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue?, using TDRKHspecific Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain tissue?, using TDRKHspecific Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Hela, using TDRKHspecific Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Hela, using TDRKHspecific Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-TDRKH antibody
Description: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Post Translational Modifications: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Subunit Structure: Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4.
Similarity: Belongs to the Tdrkh family.
Post Translational Modifications: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Subunit Structure: Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4.
Similarity: Belongs to the Tdrkh family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
Observed: 67 kDa
Predicted: 63 kDa
Predicted: 63 kDa
NCBI Official Full Name
Tudor and KH domain-containing protein
NCBI Official Synonym Full Names
tudor and KH domain containing
NCBI Official Symbol
TDRKH
NCBI Official Synonym Symbols
TDRD2
NCBI Protein Information
tudor and KH domain-containing protein
UniProt Protein Name
Tudor and KH domain-containing protein
Protein Family
UniProt Gene Name
TDRKH
UniProt Synonym Gene Names
TDRD2
UniProt Entry Name
TDRKH_HUMAN
Uniprot Description
TDRKH: a protein containing one Tudor and two KH_1 domims. Tudor domains have been shown to interact with arginine-glycine-rich motifs in a methylarginine-dependent manner, and target methylated arginines physiologically. KH domains are RNA-binding domains found in a wide variety of nucleic acid-binding proteins. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: mitochondrion
Molecular Function: RNA binding
Biological Process: fertilization; DNA methylation during gametogenesis; RNA-mediated gene silencing; gene expression; spermatogenesis; cell differentiation; male meiosis
Research Articles on TDRKH
Similar Products
Product Notes
The TDRKH tdrkh (Catalog #AAA9611519) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TDRKH Specific Antibody reacts with Human, Mouse, Rat Predicted: Pig, Bovine, Horse, Sheep, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's TDRKH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TDRKH tdrkh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TDRKH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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