Western Blot (WB)
(Western blot analysis of TCHP Antibody (Center) in CEM cell line lysates (35ug/lane). TCHP (arrow) was detected using the purified Pab.)
Rabbit anti-Human TCHP Polyclonal Antibody | anti-TCHP antibody
TCHP Antibody (Center)
Western Blot (WB)
(Western blot analysis of TCHP Antibody (Center) in CEM cell line lysates (35ug/lane). TCHP (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of TCHP Antibody (Center) in CEM cell line lysates (35ug/lane). TCHP (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human skin tissue reacted with TCHP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human skin tissue reacted with TCHP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(TCHP Antibody (Center) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(TCHP Antibody (Center) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Tokumasu,F. J. Cell. Sci. 118 (PT 5), 1091-1098 (2005)
Nishizawa,M. J. Cell. Sci. 118 (PT 5), 1081-1090 (2005)
NCBI and Uniprot Product Information
Uniprot Description
TCHP: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Belongs to the TCHP family.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: centrosome; apical cortex; mitochondrion; keratin filament; cytoplasm; plasma membrane
Molecular Function: protein binding
Biological Process: apoptosis; negative regulation of cell growth
Research Articles on TCHP
Similar Products
Product Notes
The TCHP tchp (Catalog #AAA9203017) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 291-320. The TCHP Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TCHP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the TCHP tchp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TCHP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
