Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/316.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds)
Rabbit anti-Human PDS5B Polyclonal Antibody | anti-PDS5B antibody
PDS5B Antibody
Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/316.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds)
Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/316.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Uniprot Description
APRIN: a widely expressed nuclear protein. Is lost in many cancers and may function as a tumor suppressor. Correlates with differentiation in embryonal carcinoma stem cells; its knockdown disrupted Nanog, Oct4, and SOX2 regulation. Plays a role in androgen-induced proliferative arrest in prostate cells. Is upregulated in androgen-sensitive LNCaP prostate cancer cells undergoing androgen-induced proliferative block. Required for maintenance of sister chromatid cohesion during mitosis. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Phosphorylated upon DNA damage. Maximum levels occur 18-20 hours after androgen exposure. Interacts with the cohesin complex. Phosphorylated upon DNA damage, probably by ATM or ATR. Five isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell development/differentiation
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: nucleoplasm; chromosome; cytosol; chromatin; nucleus; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; ATP binding
Biological Process: negative regulation of cell proliferation; cell proliferation; cell division; mitotic sister chromatid cohesion; mitotic cell cycle; regulation of cell proliferation
Research Articles on PDS5B
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Product Notes
The PDS5B pds5b (Catalog #AAA9403425) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDS5B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PDS5B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:200-1:1000. Researchers should empirically determine the suitability of the PDS5B pds5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDS5B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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