Rabbit TBX2 Polyclonal Antibody | anti-TBX2 antibody

TBX2 (N280) Polyclonal Antibody

Cat. Num. AAA3002097

• Gene Names: TBX2; VETD
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TBX2; Polyclonal Antibody; TBX2 (N280) Polyclonal Antibody; T-box transcription factor TBX2; T-box protein 2; anti-TBX2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TBX2 (N280) polyclonal antibody detects endogenous levels of TBX2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 712

• Applicable Applications for anti-TBX2 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human TBX2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Related Product Information for anti-TBX2 antibody

The T-box (TBX) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The TBX gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. TBX genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in TBX genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of TBX products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The TBX genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 197333868
• NCBI GeneID: 6909
• NCBI Accession #: NP_005985.3
• NCBI GenBank Nucleotide #: NP_005985.3
• UniProt Accession #: Q13207
• Molecular Weight: ~ 74kDa
• NCBI Official Full Name: T-box transcription factor TBX2
• NCBI Official Synonym Full Names: T-box transcription factor 2
• NCBI Official Symbol: TBX2
• NCBI Official Synonym Symbols: VETD
• NCBI Protein Information: T-box transcription factor TBX2
• UniProt Protein Name: T-box transcription factor TBX2
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX2
• UniProt Synonym Gene Names: T-box protein 2
• UniProt Entry Name: TBX2_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: transcription factor complex; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding

Biological Process: cardiac muscle development; transcription, DNA-dependent; positive regulation of cell proliferation; cell aging; embryonic digit morphogenesis; negative regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; palate development; negative regulation of transcription, DNA-dependent; muscle cell fate determination; positive regulation of cardiac muscle cell proliferation