Rabbit TBX18 Polyclonal Antibody | anti-TBX18 antibody

TBX18 Polyclonal Antibody

Cat. Num. AAA3006253

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TBX18; Polyclonal Antibody; TBX18 Polyclonal Antibody; T-box transcription factor TBX18; T-box protein 18; anti-TBX18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TBX18 polyclonal antibody detects endogenous levels of TBX18 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 607

• Applicable Applications for anti-TBX18 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 170-215 of Human TBX18.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TBX18 polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:NIH-3T3 cell lysateLane3:PC12 cell lysate)

Related Product Information for anti-TBX18 antibody

The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 122937456
• NCBI Accession #: NP_001073977.1
• NCBI GenBank Nucleotide #: NP_001073977.1
• UniProt Accession #: O95935
• Molecular Weight: ~ 64kDa
• NCBI Official Full Name: T-box transcription factor TBX18
• UniProt Protein Name: T-box transcription factor TBX18
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX18
• UniProt Synonym Gene Names: T-box protein 18
• UniProt Entry Name: TBX18_HUMAN

Uniprot Description

TBX18: Probable transcriptional regulator involved in developmental processes.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: nucleus

Molecular Function: protein homodimerization activity; protein heterodimerization activity; transcription factor activity

Biological Process: somitogenesis; sensory perception of sound; morphogenesis of embryonic epithelium; transcription, DNA-dependent; positive regulation of cell-cell adhesion; smooth muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; anterior/posterior axis specification

Disease: Huntington Disease