Rabbit TBR1 Polyclonal Antibody | anti-TBR1 antibody

TBR1 Polyclonal Antibody

Cat. Num. AAA3013540

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: ProA affinity purified
• Synonyms: TBR1; Polyclonal Antibody; TBR1 Polyclonal Antibody; TBR-1; T box brain 1; T box brain protein 1; T brain 1 protein; T-box brain protein 1; T-brain-1; TBR 1; Tbr1; TES 56; TES-56; anti-TBR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TBR1 polyclonal antibody detects endogenous levels of TBR1 protein.
• Purity/Purification: ProA affinity purified
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 682

• Applicable Applications for anti-TBR1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:500-1:1,000; FC/FACS: 1:50-1:100; IHC: 1:50-1:200
• Immunogen: recombinant protein
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C or -80 degree C.; Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-TBR1 antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-TBR1 antibody. Counter stained with hematoxylin.)

Related Product Information for anti-TBR1 antibody

A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury (T) gene that is expressed only in postmitotic cells. T-brain-1 (TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex. TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies. CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence (the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin.

NCBI and Uniprot Product Information

• NCBI GI #: 5730081
• NCBI GeneID: 680427
• NCBI Accession #: NP_006584
• NCBI GenBank Nucleotide #: NP_006584.1
• UniProt Accession #: Q16650; Q64336
• Molecular Weight: 74kDa
• NCBI Official Full Name: T-box brain protein 1
• NCBI Official Synonym Full Names: T-box brain transcription factor 1
• NCBI Official Symbol: Tbr1
• NCBI Protein Information: T-box brain protein 1
• UniProt Protein Name: T-box brain protein 1
• Protein Family: T-box protein
• UniProt Gene Name: TBR1
• UniProt Synonym Gene Names: T-brain-1; TBR-1
• UniProt Entry Name: TBR1_HUMAN