Rabbit TBKBP1 Polyclonal Antibody | anti-TBKBP1 antibody

Rabbit Polyclonal to Human TBKBP1

Cat. Num. AAA244457

• Gene Names: TBKBP1; SINTBAD; ProSAPiP2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: TBKBP1; Polyclonal Antibody; Rabbit Polyclonal to Human TBKBP1; Anti-TBKBP1 Antibody (aa300-350) IHC-plus; KIAA0775; TBK1 binding protein 1; ProSAPiP2; TBK1-binding protein 1; SINTBAD; Human TBKBP1; anti-TBKBP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human TBKBP1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.05% BSA, 0.05% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 615

• Applicable Applications for anti-TBKBP1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (0.5 - 4 ug/ml)
• Target Species: Human
• Immunogen Description: A portion of amino acids 300-350 of human SINTBAD/TBKBP1 was used as the immunogen.
• Immunogen Type: Synthetic peptide
• Immunogen: TBKBP1 antibody was raised against a portion of amino acids 300-350 of human SINTBAD/TBKBP1 was used as the immunogen.
• Antigen Modification: aa300-350
• Preparation and Storage: Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-TBKBP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of SINTBAD/TBKBP1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide 3) mouse brain and 4) rat brain using at 4.0 ug/ml, 0.5 ug/ml and 1.0 ug/ml, respectively. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.)

NCBI and Uniprot Product Information

• NCBI GI #: 7662302
• NCBI GeneID: 9755
• NCBI Accession #: NP_055541.1
• NCBI GenBank Nucleotide #: NM_014726.2
• UniProt Accession #: A7MCY6; O94873; Q14DW3; B2RZG6
• Molecular Weight: 25,043 Da
• NCBI Official Full Name: TANK-binding kinase 1-binding protein 1
• NCBI Official Synonym Full Names: TBK1 binding protein 1
• NCBI Official Symbol: TBKBP1
• NCBI Official Synonym Symbols: SINTBAD; ProSAPiP2
• NCBI Protein Information: TANK-binding kinase 1-binding protein 1; TBKBP1; TBK1-binding protein 1
• UniProt Protein Name: TANK-binding kinase 1-binding protein 1
• Protein Family: TANK-binding kinase 1-binding protein
• UniProt Gene Name: TBKBP1
• UniProt Synonym Gene Names: TBK1-binding protein 1
• UniProt Entry Name: TBKB1_HUMAN

NCBI Description

TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

Uniprot Description

TBKBP1: Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity. Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q21.32

Molecular Function: protein binding

Biological Process: innate immune response