Rabbit TAX1BP1 Polyclonal Antibody | anti-TAX1BP1 antibody

TAX1BP1 Polyclonal Antibody

Cat. Num. AAA2526043

• Gene Names: TAX1BP1; T6BP; TXBP151; CALCOCO3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: TAX1BP1; Polyclonal Antibody; TAX1BP1 Polyclonal Antibody; T6BP; TXBP151; CALCOCO3; anti-TAX1BP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2mg/mL (varies by lot)
• Sequence Length: 590

• Applicable Applications for anti-TAX1BP1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Immunogen: Recombinant protein of human TAX1BP1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TAX1BP1 Polyclonal Antibody at dilution 1:60)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TAX1BP1 Polyclonal Antibody at dilution 1:60)

Related Product Information for anti-TAX1BP1 antibody

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [

NCBI and Uniprot Product Information

• NCBI GI #: 332634744
• NCBI GeneID: 8887
• NCBI Accession #: NP_001193831.1
• NCBI GenBank Nucleotide #: NM_001206902.1
• Molecular Weight: 68,277 Da
• NCBI Official Full Name: tax1-binding protein 1 isoform 3
• NCBI Official Synonym Full Names: Tax1 (human T-cell leukemia virus type I) binding protein 1
• NCBI Official Symbol: TAX1BP1
• NCBI Official Synonym Symbols: T6BP; TXBP151; CALCOCO3
• NCBI Protein Information: tax1-binding protein 1; TRAF6-binding protein
• UniProt Protein Name: Tax1-binding protein 1
• Protein Family: Tax1-binding protein
• UniProt Gene Name: TAX1BP1
• UniProt Synonym Gene Names: T6BP
• UniProt Entry Name: TAXB1_HUMAN

NCBI Description

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Uniprot Description

TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; kinase binding

Biological Process: apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interferon type I production; negative regulation of apoptosis