Rabbit anti-Human Tau Polyclonal Antibody | anti-tau antibody

Tau, phosphorylated (Ser356) (Tau Protein, Microtubule-associated Protein, MAP)

Cat. Num. AAA626261

• Gene Names: tau; BcDNA:RE16764; CG12881; CG31057; CG5606; DmelCG31057; dtau
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Tau; Polyclonal Antibody; phosphorylated (Ser356) (Tau Protein; Microtubule-associated Protein; MAP); Anti -Tau; anti-tau antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human tau. Species sequence homology: mouse, rat, rhesus monkey, baboon, bovine, and goat (100%).
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.3, 0.05% sodium azide, 50% glycerol.

• Applicable Applications for anti-tau antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:1000.; Optimal dilutions to be determined by researcher.
• Immunogen: Synthetic phosphopeptide derived from a region of human tau that contains serine 356.
• Positive Control: Recombinant human tau left untreated, or treated with PKA.; ; Storage and Stability:; May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Preparation and Storage: 4 degree C (-20 degree C Glycerol)

Related Product Information for anti-tau antibody

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylated tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyper-phosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases, including GSK-3b, protein kinase A (PKA), cyclin-dependent kinase 5 and casein kinase II, phosphorylate tau. Serine 356 can be phosphorylated by GSK-3b, PKA and MAP kinase and has been found to be a major site in AD brain. This antibody, combined with the tau [pS262] antibody, enables one to distinguish between phosphorylation at the two distinct residues, rather than a combined epitope as detected by 12E8 antibody.

Product Categories/Family for anti-tau antibody

Antibodies; Abs to Microtubule-associated Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 21357661
• NCBI GeneID: 326116
• NCBI Accession #: NP_651575.1
• NCBI GenBank Nucleotide #: NM_143318.2
• NCBI Official Full Name: tau
• NCBI Official Symbol: tau
• NCBI Official Synonym Symbols: BcDNA:RE16764; CG12881; CG31057; CG5606; DmelCG31057; dtau
• NCBI Protein Information: CG31057 gene product from transcript CG31057-RA; tau; CG31057-PA; tau-PA
• Protein Family: Tautomerase