Rabbit anti-Human Tau Polyclonal Antibody | anti-MAPT antibody

Anti-Tau Antibody, Rabbit Polyclonal

Cat. Num. AAA8100513

• Gene Names: MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: Tau; Polyclonal Antibody; Anti-Tau Antibody; Rabbit Polyclonal; MAPT/PHF-tau Antibody; Rabbit PAb; microtubule-associated protein tau; Anti-DDPAC Antibody; Anti-FTDP-17 Antibody; Anti-MAPT Antibody; Anti-MAPTL Antibody; Anti-MSTD Antibody; Anti-MTBT1 Antibody; Anti-MTBT2 Antibody; Anti-PPND Antibody; Anti-PPP1R103 Antibody; Anti-TAU Antibody; anti-MAPT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human MAPT/PHF-tau
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-MAPT antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human MAPT/PHF-tau protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human MAPT/PHF-tau (rh MAPT). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-MAPT antibody

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development-possibly because of compensation in tau deficiency by other MAPs.

Product Categories/Family for anti-MAPT antibody

AMPK Signaling Pathway

References

Harada A, et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369(6480):488-91. Weingarten MD, et al. (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci. 72(5):1858-62. Goedert M, et al. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 3(4): 519-26.

NCBI and Uniprot Product Information

• NCBI GI #: 8400715
• NCBI GeneID: 4137
• NCBI Accession #: NP_058525.1
• NCBI GenBank Nucleotide #: NM_016841.4
• NCBI Official Full Name: microtubule-associated protein tau isoform 4
• NCBI Official Synonym Full Names: microtubule associated protein tau
• NCBI Official Symbol: MAPT
• NCBI Official Synonym Symbols: TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• NCBI Protein Information: microtubule-associated protein tau
• Protein Family: Tautomerase

NCBI Description

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]