MAPT / Tau recombinant protein

Recombinant Human MAPT / Tau Protein (His tag)

Cat. Num. AAA2546558

• Gene Names: MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• Purity: > 85 % as determined by SDS-PAGE
• Synonyms: MAPT / Tau; Recombinant Human MAPT / Tau Protein (His tag); MAPT; MAPTL; MTBT1; TAU; MAPT / Tau recombinant protein

• Host: E Coli
• Purity/Purification: > 85 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 352

• Application Notes: The recombinant human MAPT consists of 367 amino acids and predicts a molecular mass of 38.7 KDa. It migrates as an approximately 40-50 KDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: His
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for MAPT / Tau recombinant protein

Background: MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

Description: A DNA sequence encoding the mature form of human MAPT (NP_058525.1) (Ala2-Leu352) was expressed with a polyhistide tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 8400715
• NCBI GeneID: 4137
• NCBI Accession #: NP_058525.1
• NCBI GenBank Nucleotide #: NM_016841.4
• NCBI Official Full Name: microtubule-associated protein tau isoform 4
• NCBI Official Synonym Full Names: microtubule associated protein tau
• NCBI Official Symbol: MAPT
• NCBI Official Synonym Symbols: TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• NCBI Protein Information: microtubule-associated protein tau

NCBI Description

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]