Rabbit TAOK1 / TAO1 Polyclonal Antibody | anti-TAOK1 antibody

Rabbit Polyclonal (IgG) to Human TAOK1 / TAO1

Cat. Num. AAA244036

• Gene Names: TAOK1; PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TAOK1 / TAO1; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human TAOK1 / TAO1; Anti-TAOK1 / TAO1 Antibody (aa431-480) IHC-plus; TAOK1; MAP3K16; MARK Kinase; HKFC-B; KFC-B; TAO kinase 1; TAO1; MARKK; PSK2; HTAOK1; KIAA1361; Kinase from chicken homolog B; PSK-2; Rat TAO1; STE20-like kinase PSK2; Sulu3; Human TAOK1; anti-TAOK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAOK1 Antibody detects endogenous levels of total TAOK1 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1001

• Applicable Applications for anti-TAOK1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:5000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TAOK1 (aa431-480).
• Immunogen: TAOK1 / TAO1 antibody was raised against synthetic peptide from human TAOK1 (aa431-480).
• Antigen Modification: aa431-480
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-TAO1 / TAOK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.)

Western Blot (WB)

(Western blot of extracts from NIH-3T3 cells, using TAOK1 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-TAOK1 antibody

TAOK1 is a TAO type protein kinase. TAOK1 enhances microtubule dynamics through the activation of MARK (microtubule affinity regulating kinase) that leads to phosphorylation and detachment of tau and other MAPs from microtubules causing destabilization. TAOK1 also interacts via downstream targets such as JNK and ROCK-1 to regulate apoptotic morphology associated with the execution phase of apoptosis, which involves reorganization of the actin cytoskeleton.

Product Categories/Family for anti-TAOK1 antibody

Family: Protein Kinase; Subfamily: TAO

NCBI and Uniprot Product Information

• NCBI GI #: 45439370
• NCBI GeneID: 57551
• NCBI Accession #: NP_065842.1
• NCBI GenBank Nucleotide #: NM_020791.2
• UniProt Accession #: Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6; A2RUT8; B7ZLV6
• Molecular Weight: 97,526 Da
• NCBI Official Full Name: serine/threonine-protein kinase TAO1 isoform 1
• NCBI Official Synonym Full Names: TAO kinase 1
• NCBI Official Symbol: TAOK1
• NCBI Official Synonym Symbols: PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16
• NCBI Protein Information: serine/threonine-protein kinase TAO1; MARK Kinase; STE20-like kinase PSK2; kinase from chicken homolog B; prostate-derived STE20-like kinase 2; thousand and one amino acid protein 1; prostate-derived sterile 20-like kinase 2; serine/threonine protein kinase TAO1 homolog; thousand and one amino acid protein kinase 1; microtubule affinity regulating kinase kinase
• UniProt Protein Name: Serine/threonine-protein kinase TAO1
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: TAOK1
• UniProt Synonym Gene Names: KIAA1361; MAP3K16; MARKK; hKFC-B; MARKK; PSK-2; PSK2; Prostate-derived STE20-like kinase 2; TAOK1; hTAOK1
• UniProt Entry Name: TAOK1_HUMAN

Uniprot Description

TAO1: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; TAO subfamily

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytosol

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: activation of MAPKK activity; spindle checkpoint; MAPKKK cascade; positive regulation of JNK cascade; mitotic cell cycle; G2/M transition DNA damage checkpoint; DNA repair; protein amino acid phosphorylation; response to DNA damage stimulus; positive regulation of stress-activated MAPK cascade; regulation of cytoskeleton organization and biogenesis