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Immunohistochemistry (IHC) (Anti-Neurokinin A Receptor antibody IHC of human small intestine, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit TACR2 / Nk2 / NK2R Polyclonal Antibody | anti-TACR2 antibody

Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R

Gene Names
TACR2; SKR; NK2R; NKNAR; TAC2R
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
TACR2 / Nk2 / NK2R; Polyclonal Antibody; Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R; Anti-TACR2 / Nk2 / NK2R Antibody (C-Terminus) IHC-plus; TACR2; Neurokinin 2 receptor; NK-2 receptor; Neurokinin A receptor; NK2; NK2R; Tachykinin receptor 2; Substance-K receptor; NK-2R; SK receptor; SKR; TAC2R; NKNAR; Substance K receptor; Human TACR2; Nk2; anti-TACR2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human Neurokinin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
398
Applicable Applications for anti-TACR2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (5 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Marmoset (90%); Monkey (85%); Bovine, Rabbit (80%).
Immunogen Type
Synthetic peptide
Immunogen
TACR2 / Nk2 / NK2R antibody was raised against synthetic 20 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Marmoset (90%); Monkey (85%); Bovine, Rabbit (80%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-Neurokinin A Receptor antibody IHC of human small intestine, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-Neurokinin A Receptor antibody IHC of human small intestine, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-TACR2 / Nk2 / NK2R antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-TACR2 / Nk2 / NK2R antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-TACR2 antibody
NK2R is a Tachykinin Receptor activated by the neuropeptide substance K, also referred to as neurokinin A. It mediates smooth muscle contraction in central airway and may contribute to the development of asthma.
Product Categories/Family for anti-TACR2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
44,442 Da
NCBI Official Full Name
substance-K receptor
NCBI Official Synonym Full Names
tachykinin receptor 2
NCBI Official Symbol
TACR2
NCBI Official Synonym Symbols
SKR; NK2R; NKNAR; TAC2R
NCBI Protein Information
substance-K receptor; NK-2R; NK-2 receptor; substance K receptor; neurokinin 2 receptor; neurokinin A receptor; seven transmembrane helix receptor
UniProt Protein Name
Substance-K receptor
Protein Family
UniProt Gene Name
TACR2
UniProt Synonym Gene Names
NK2R; NKNAR; TAC2R; SKR; NK-2R
UniProt Entry Name
NK2R_HUMAN

NCBI Description

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

Uniprot Description

TACR2: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: substance K receptor activity; protein binding; tachykinin receptor activity

Biological Process: negative regulation of luteinizing hormone secretion; tachykinin signaling pathway; intestine smooth muscle contraction; muscle contraction; operant conditioning; response to electrical stimulus; excretion; positive regulation of vascular permeability; positive regulation of acetylcholine secretion

Research Articles on TACR2

Similar Products

Product Notes

The TACR2 tacr2 (Catalog #AAA243799) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R reacts with Gorilla, Human Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's TACR2 / Nk2 / NK2R can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (5 ug/ml). Researchers should empirically determine the suitability of the TACR2 tacr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TACR2 / Nk2 / NK2R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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