Rabbit anti-Human TACO1 Polyclonal Antibody | anti-TACO1 antibody

TACO1, NT (TACO1, CCDC44, Translational activator of cytochrome c oxidase 1, Coiled-coil domain-containing protein 44, Translational activator of mitochondrially-encoded cytochrome c oxidase I) (Biotin)

Cat. Num. AAA6353250

• Gene Names: TACO1; CCDC44
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TACO1; Polyclonal Antibody; NT (TACO1; CCDC44; Translational activator of cytochrome c oxidase 1; Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase I) (Biotin); Translational activator of mitochondrially-encoded cytochrome c oxidase I; anti-TACO1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TACO1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TACO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human TACO1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TACO1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TACO1 Antibody detected the TACO1 protein (arrow).)

Related Product Information for anti-TACO1 antibody

This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.

Product Categories/Family for anti-TACO1 antibody

Antibodies; Enzymes; Cytochrome

References

Weraarpachai, W., et al. Nat. Genet. 41(7):833-837(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 27545315
• NCBI GeneID: 51204
• NCBI Accession #: NP_057444.2
• NCBI GenBank Nucleotide #: NM_016360.3
• UniProt Accession #: Q9BSH4; Q8N3N6; Q9UI60; B2RD21
• Molecular Weight: 32,477 Da
• NCBI Official Full Name: translational activator of cytochrome c oxidase 1
• NCBI Official Synonym Full Names: translational activator of mitochondrially encoded cytochrome c oxidase I
• NCBI Official Symbol: TACO1
• NCBI Official Synonym Symbols: CCDC44
• NCBI Protein Information: translational activator of cytochrome c oxidase 1; clone HQ0477 PRO0477p; coiled-coil domain-containing protein 44
• UniProt Protein Name: Translational activator of cytochrome c oxidase 1
• Protein Family: Translational activator of cytochrome c oxidase
• UniProt Gene Name: TACO1
• UniProt Synonym Gene Names: CCDC44
• UniProt Entry Name: TACO1_HUMAN

NCBI Description

This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

Uniprot Description

CCDC44: Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1. Defects in TACO1 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency. Belongs to the TACO1 family.

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: nucleoplasm; mitochondrion; nucleus

Biological Process: regulation of translation

Disease: Mitochondrial Complex Iv Deficiency