Rabbit CA8 Polyclonal Antibody | anti-CA8 antibody

CA8 Rabbit Polyclonal

Cat. Num. AAA767398

• Gene Names: CA8; CALS; CARP; CA-RP; CAMRQ3; CA-VIII
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CA8; Polyclonal Antibody; CA8 Rabbit Polyclonal; anti-CA8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 258

• Applicable Applications for anti-CA8 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Carbonic anhydrase VIII
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas using MBS767398 (CA8 antibody) at dilution of 1:100)

Testing Data

()

Western Blot (WB)

(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS767398 (CA8 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 1012443763
• NCBI GeneID: 767
• NCBI Accession #: NP_001308768.1
• NCBI GenBank Nucleotide #: NM_001321839.1
• Molecular Weight: 32,973 Da
• NCBI Official Full Name: carbonic anhydrase-related protein isoform c
• NCBI Official Synonym Full Names: carbonic anhydrase 8
• NCBI Official Symbol: CA8
• NCBI Official Synonym Symbols: CALS; CARP; CA-RP; CAMRQ3; CA-VIII
• NCBI Protein Information: carbonic anhydrase-related protein
• UniProt Protein Name: Carbonic anhydrase-related protein
• Protein Family: Carbonic anhydrase-related protein
• UniProt Gene Name: CA8
• UniProt Synonym Gene Names: CALS; CARP; CA-VIII
• UniProt Entry Name: CAH8_HUMAN

NCBI Description

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

CA8: Does not have a carbonic anhydrase catalytic activity. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation. Belongs to the alpha-carbonic anhydrase family.

Protein type: Energy Metabolism - nitrogen; Lyase

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: cytoplasm

Molecular Function: carbonate dehydratase activity; protein binding; zinc ion binding

Biological Process: one-carbon compound metabolic process; phosphoinositide-mediated signaling

Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 3