Immunohistochemistry (IHC)
Rabbit anti-Mouse, Rat Syncytin 1 Polyclonal Antibody | anti-Ervfrd-1 antibody
Syncytin 1 Antibody
Gene Names
Ervfrd-1; Gm52; Syna
Reactivity
Mouse, Rat
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Immobilized antigen affinity chromatography
Synonyms
Syncytin 1; Polyclonal Antibody; Syncytin 1 Antibody; Affinity Purified Envelope glycoprotein syncytin-A Antibody; Endogenous retrovirus group W member 1 antibody; env antibody; Env-W antibody; Envelope polyprotein gPr73 antibody; Enverin antibody; ERVW antibody; ERVW-1 antibody; Gp24 antibody; Gp50 antibody; HERV-7q Envelope protein antibody; HERV-W envelope protein antibody; HERVW antibody; SU antibody; Syncytin 1 antibody; TM antibody; Transmembrane protein antibody; anti-Ervfrd-1 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
618
Applicable Applications for anti-Ervfrd-1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 1:50,000
IHC: 1:50-1:100
IP: 1:200
WB: 1:500
IHC: 1:50-1:100
IP: 1:200
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 180-230 on rat Envelope glycoprotein syncytin-A protein.
Conjugation
Unconjugated
Molecular Function
Anatomical structure morphogenesis; syncytium formation
Subcellular Location
Cell Membrane
Preparation and Storage
Store at -20 degree C for long term storage.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-Ervfrd-1 antibody
Overview: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
Structure: The cytoplasmic region is essential for the fusiogenic function. The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
Expression: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
Structure: The cytoplasmic region is essential for the fusiogenic function. The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
Expression: Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
68,830 Da
NCBI Official Full Name
envelope glycoprotein syncytin-A
NCBI Official Synonym Full Names
endogenous retrovirus group FRD member 1, envelope
NCBI Official Symbol
Ervfrd-1
NCBI Official Synonym Symbols
Gm52; Syna
NCBI Protein Information
envelope glycoprotein syncytin-A
UniProt Protein Name
Endogenous retrovirus group FRD member 1, envelope
Protein Family
UniProt Gene Name
Ervfrd-1
NCBI Description
Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a endogenous retrovirus provirus on rat chromosome 12 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]
Similar Products
Product Notes
The Ervfrd-1 ervfrd-1 (Catalog #AAA5400810) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Syncytin 1 Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Syncytin 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:50,000 IHC: 1:50-1:100 IP: 1:200 WB: 1:500. Researchers should empirically determine the suitability of the Ervfrd-1 ervfrd-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Syncytin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
