Rabbit anti-Mouse, Rat Synapsin II Polyclonal Antibody | anti-SYN2 antibody

Synapsin II

Cat. Num. AAA614108

• Gene Names: SYN2; SYNII; SYNIIa; SYNIIb
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A chromatography
• Synonyms: Synapsin II; Polyclonal Antibody; Anti -Synapsin II; anti-SYN2 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects ~74 and ~54kD proteins, corresponding to the apparent molecular masses of synapsin IIa and IIb on SDS-PAGE immunoblots, in samples from mouse and rat.
• Purity/Purification: Affinity Purified; Purified by Protein A chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 50% glycerol, 0.09% azide.

• Applicable Applications for anti-SYN2 antibody: Western Blot (WB)
• Immunogen: A 14 residue synthetic peptide ASPGPERRPPPAQA based on the rat synapsin II (residues 52-65) was synthesized and the peptide coupled to KLH. This sequence is identical to mouse synapsin II of these residues.
• Preparation and Storage: -20 degree C

Related Product Information for anti-SYN2 antibody

Synapsin IIa and IIb are 74 and 54kD proteins that coat synaptic vesicles (2). Their homolog, synapsin I, may function as an adaptor that tethers the reserved pool of synaptic vesicles to the cytoskeleton meshwork. Depletion of synapsin II expression by antisense oligonucleotides prevents axon elongation in cultured rat hippocampal neurons (3). Depletion of this protein also causes abnormal distribution of intracellular filamentous actin and decreases in the amounts of several synaptic vesicle-associated proteins (3). Genetic studies have shown that mice lacking synapsin I and II are viable but experience seizures with a frequency proportional to the number of mutant alleles (4). Synapsin II knockout mice exhibit decreased post-tetanic potentiation and severe synaptic depression upon repetitive stimulation. This phenotype can be explained by synapsin serving as a regulator in providing fusion-competent synaptic vesicles at the active zone during increased rate of vesicle transport (4). Dephosphorylated synapsin II induces actin polymerization whereas PKA-dependent phosphorylation reduces its ability to interact with actin monomers and filaments (5). The large central domain in synapsin II has been shown to bind ATP in a Ca2+-independent manner (6).

Product Categories/Family for anti-SYN2 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 927424
• NCBI GeneID: 6854
• UniProt Accession #: Q15530; Q59GM1; Q86VA8; Q92777
• Molecular Weight: 4,219 Da
• NCBI Official Full Name: synapsin II
• NCBI Official Synonym Full Names: synapsin II
• NCBI Official Symbol: SYN2
• NCBI Official Synonym Symbols: SYNII; SYNIIa; SYNIIb
• NCBI Protein Information: synapsin-2; OTTHUMP00000222077; OTTHUMP00000222078
• UniProt Protein Name: Synapsin II
• Protein Family: Synapsin
• UniProt Gene Name: syn2
• UniProt Entry Name: Q15530_HUMAN

NCBI Description

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts. [provided by RefSeq]

Uniprot Description

SYN2: neuronal phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal and to the cytoskeleton. May function in the regulation of neurotransmitter release and synaptogenesis. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing results in two isoforms.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: synaptic vesicle membrane; synapse; cell junction

Molecular Function: catalytic activity; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion

Disease: Schizophrenia