Testing Data
(Detection of Survivin [Ser20] in phosphorylated recombinant protein (+), but not in unphosphorylated protein (-) using NB110-92717.)
Rabbit anti-Human Survivin Polyclonal Antibody | anti-LOC398389 antibody
Survivin, phosphorylated (Ser20) (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)
Reactivity
Human
Applications
Western Blot
Purity
PurifiedPurified.
Synonyms
Survivin; Polyclonal Antibody; phosphorylated (Ser20) (Apoptosis Inhibitor 4; Apoptosis Inhibitor-4; API4; Apoptosis Inhibitor Survivin; Baculoviral IAP Repeat-containing 5; BIRC5; BIRC-5; EPR1; EPR-1; IAP4; SVV; TIAP); Anti -Survivin; anti-LOC398389 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Recognizes human Survivin when phosphorylated at Ser20 at ~16.5kD..
Purity/Purification
Purified
Purified.
Purified.
Form/Format
Supplied as a liquid in PBS, 30% Glycerol, 0.1% sodium azide.
Applicable Applications for anti-LOC398389 antibody
Western Blot (WB)
Application Notes
Dilution: Western Blot: 3ug/ml
Immunogen
Synthetic phosphopeptide surrounding the phosphorylated serine 20 of the human Survivin protein. [Swiss-Prot #O15392]
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Testing Data
(Detection of Survivin [Ser20] in phosphorylated recombinant protein (+), but not in unphosphorylated protein (-) using NB110-92717.)
Testing Data
(Detection of Survivin [Ser20] in phosphorylated recombinant protein (+), but not in unphosphorylated protein (-) using NB110-92717.)
Related Product Information for anti-LOC398389 antibody
Survivin is a structurally unique inhibitor of apoptosis (IAP) that has been linked to protection from apoptosis, control of cell division, and cellular adaptation to stress. In order for survivin to provide this cytoprotection an interaction with at least one other IAP, such as XIAP, is necessary. It has recently been shown that Survivin is phosphorylated at Ser20 by protein kinase A (PKA) in the cytosol but not in the mitochondria. This phosphorylation on Ser20 disrupts the binding of cytosolic survivin to XIAP and therefore diminishes survivin's cytoprotective properties.
Product Categories/Family for anti-LOC398389 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
survivin
NCBI Official Symbol
LOC398389
NCBI Protein Information
survivin
Research Articles on LOC398389
Similar Products
Product Notes
The LOC398389 (Catalog #AAA631235) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Survivin, phosphorylated (Ser20) (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Survivin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Dilution: Western Blot: 3ug/ml. Researchers should empirically determine the suitability of the LOC398389 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Survivin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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