Rabbit SUMO3 Polyclonal Antibody | anti-SUMO3 antibody

SUMO3 Antibody

Cat. Num. AAA9413600

• Gene Names: SUMO3; SMT3A; Smt3B; SMT3H1; SUMO-3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SUMO3; Polyclonal Antibody; SUMO3 Antibody; Small ubiquitin-related modifier 3; SMT3 suppressor of mif two 3 homolog 3; SMT3A; SMT3H1; SMT3 homolog 1; anti-SUMO3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 103

• Applicable Applications for anti-SUMO3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 13 amino acid peptide near the carboxy terminus of human SUMO3.
• Target Name: SUMO3
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SUMO3 in mouse liver tissue lysate with SUMO3 antibody at (A) and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SUMO2/3 in rat liver tissue with SUMO2/3 antibody at 5 ug/mL.)

Related Product Information for anti-SUMO3 antibody

Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (Sumo-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, which is a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. All SUMO proteins localize to the nucleus and are covalently conjugated, affecting protein structure, function and interactions. SUMO2 and 3 are 96% identical and are more mobile within nucleus relative to SUMO1. Specific functional differences between SUMO1 and SUMO2 and 3 remain to be identified.

Product Categories/Family for anti-SUMO3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 48928058
• NCBI GeneID: 6612
• NCBI Accession #: NP_008867
• NCBI GenBank Nucleotide #: NM_006936.2
• Molecular Weight: 15,768 Da
• NCBI Official Full Name: small ubiquitin-related modifier 3 isoform 1
• NCBI Official Synonym Full Names: small ubiquitin-like modifier 3
• NCBI Official Symbol: SUMO3
• NCBI Official Synonym Symbols: SMT3A; Smt3B; SMT3H1; SUMO-3
• NCBI Protein Information: small ubiquitin-related modifier 3
• UniProt Protein Name: Small ubiquitin-related modifier 3
• Protein Family: Small ubiquitin-related modifier
• UniProt Gene Name: SUMO3
• UniProt Synonym Gene Names: Smt3A
• UniProt Entry Name: SUMO3_HUMAN

NCBI Description

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

Uniprot Description

SUMO3: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Expressed predominantly in liver. Belongs to the ubiquitin family. SUMO subfamily.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; kinetochore; PML body; cytoplasm; nucleus

Molecular Function: protein binding; SUMO ligase activity

Biological Process: cellular protein metabolic process; protein sumoylation; post-translational protein modification