Rabbit STOML2 Polyclonal Antibody | anti-STOML2 antibody

STOML2 Antibody

Cat. Num. AAA9603238

• Gene Names: STOML2; SLP-2; HSPC108
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: STOML2; Polyclonal Antibody; STOML2 Antibody; EPB72 like protein 2; EPB72-like protein 2; HSPC108; OTTHUMP00000021320; Paraprotein target 7; Paratarg 7; SLP 2; SLP-2; SLP2; STML2_HUMAN; Stomatin (EPB72) like 2; Stomatin like 2; Stomatin like protein 2; mitochondrial; Stomatin-like protein 2; anti-STOML2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: STOML2 antibody detects endogenous levels of STOML2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 311

• Applicable Applications for anti-STOML2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: A synthesized peptide derived from human STOML2.
• Subcellular Location: Membrane. Cytoplasm. Cytoplasm > Cytoskeleton. Associated with the cytoskeleton.
• Tissue Specificity: Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).
• Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Xenopus
• Similarity: Pig (100%), Zebrafish (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Xenopus (92%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(MBS9603238 at 1/100 staining Human lymph tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.)

Western Blot (WB)

(Western blot analysis of extracts of C6 cells, using STOML2 antibody.)

Related Product Information for anti-STOML2 antibody

Function: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
Subunit Structure: Forms homooligomers. Interacts with MFN2; may form heterooligomers. Interacts with CACNA2D2 (By similarity). Interacts with PHB and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them.
Post-translational Modifications: Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.
Similarity: Belongs to the band 7/mec-2 family.

NCBI and Uniprot Product Information

• NCBI GI #: 559098406
• NCBI GeneID: 30968
• NCBI Accession #: NP_001273960.1
• NCBI GenBank Nucleotide #: NM_001287031.1
• UniProt Accession #: Q9UJZ1; O60376; Q53G29; Q96FY2; Q9P042; B4E1K7; D3DRN3
• Molecular Weight: Observed: 39 kDa; Predicted: 39 kDa
• NCBI Official Full Name: stomatin-like protein 2, mitochondrial isoform b
• NCBI Official Synonym Full Names: stomatin like 2
• NCBI Official Symbol: STOML2
• NCBI Official Synonym Symbols: SLP-2; HSPC108
• NCBI Protein Information: stomatin-like protein 2, mitochondrial
• UniProt Protein Name: Stomatin-like protein 2, mitochondrial
• Protein Family: Stomatin-like protein
• UniProt Gene Name: STOML2
• UniProt Synonym Gene Names: SLP2; SLP-2; Paratarg-7

Uniprot Description

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.