Rabbit anti-Human STK38L Polyclonal Antibody | anti-STK38L antibody

STK38L, CT (Serine/Threonine-protein Kinase 38-like, NDR2 Protein Kinase, Nuclear Dbf2-related Kinase 2, KIAA0965, NDR2) (Biotin)

Cat. Num. AAA6501234

• Gene Names: STK38L; NDR2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: STK38L; Polyclonal Antibody; CT (Serine/Threonine-protein Kinase 38-like; NDR2 Protein Kinase; Nuclear Dbf2-related Kinase 2; KIAA0965; NDR2) (Biotin); anti-STK38L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human STK38L.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-STK38L antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:250-1:500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human STK38L (KLH).
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(The anti-STK38L Pab is used in Western blot to detect STK38L in Jurkat and T47D cell line lysates.)

Western Blot (WB)

(Western blot analysis of anti-STK38L Pab transiently transfected HEK-293 cell line lysate (1ug/lane). STK38L pab(arrow) was detected using the purified Pab)

Product Categories/Family for anti-STK38L antibody

Antibodies; Protein Kinases

References

1. Devroe, E., et al., J. Biol. Chem. 279(23):24444-24451 (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 24307971
• NCBI GeneID: 23012
• NCBI Accession #: NP_055815
• NCBI GenBank Nucleotide #: NM_015000
• UniProt Accession #: Q9Y2H1
• Molecular Weight: 54kDa
• NCBI Official Full Name: serine/threonine-protein kinase 38-like
• NCBI Official Synonym Full Names: serine/threonine kinase 38 like
• NCBI Official Symbol: STK38L
• NCBI Official Synonym Symbols: NDR2
• NCBI Protein Information: serine/threonine-protein kinase 38-like
• UniProt Protein Name: Serine/threonine-protein kinase 38-like
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: STK38L

Uniprot Description

NDR2: a non-receptor S/T kinase of the AGC group. Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind followed by autophosphorylation of a serine in the kinase domain. A threonine in the C-terminal domain then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between the phosphorylated threonine and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. May be involved in the regulation of structural processes in neuronal cells.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12p11.23

Cellular Component: actin cytoskeleton; cytoplasm; cytosol

Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of cellular component organization and biogenesis