Rabbit STAT 5 Polyclonal Antibody | anti-Stat92E antibody

STAT 5, phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5, STAT5, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Signal Transducer And Activator Of Transcription 5B)

Cat. Num. AAA629467

• Gene Names: Stat92E; CG4257; d-STAT; D-stat; D-Stat; D-STAT; D-stat/stat92E; DmelCG4257; DmSTAT; DRODSRC; DSRC; dstat; dSTAT; Dstat; DSTAT; Dstat 92E; dSTAT92E; Dstat92E; dSTAT92E/marelle; l(3)06346; l(3)j6C8; mrl; mrL; mrl stat92E; pSTAT; SD-stat; stat; Stat; STAT; STAT 92E
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: STAT 5; Polyclonal Antibody; phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5; STAT5; Signal Transducer and Activator of Transcription 5A; STAT5A; STAT5B; Signal Transducer And Activator Of Transcription 5B); Anti -STAT 5; anti-Stat92E antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes endogenous levels of human STAT5 when phosphorylated at tyrosine 694. Species Crossreactivity: mouse and rat
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-Stat92E antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot:1:500-1:1,000; Immunohistochemistry:1:50-1:100
• Immunogen: Synthetic phosphopeptide corresponding to human STAT5 around the phosphorylation site of tyrosine 694 (D-G-YP-V-K).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Stat92E antibody

STATs, such as STAT5, are proteins that serve the dual function of signal transducers and activators of transcription in cells exposed to signaling polypeptides. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. STAT5A and STAT5B knockout mice show important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Abnormal activity of certain STAT family members, particularly STAT3 and STAT5, is associated with a wide variety of human malignancies, including hematologic, breast, head and neck, and prostate cancers. STAT5A and STAT6, are selectively activated when the heart is subjected to ischemic injury, whereas activation of STAT3 and STAT5A is involved in myocardial hypertrophy. STAT5 and STAT3, as these two STAT molecules are required for normal breast development and involution, respectively, and may play an important role in breast carcinogenesis.

Product Categories/Family for anti-Stat92E antibody

Antibodies; Abs to Transcription Factors; STAT

NCBI and Uniprot Product Information

• NCBI GI #: 442620068
• NCBI GeneID: 42428
• NCBI Accession #: NP_001262762.1
• NCBI GenBank Nucleotide #: NM_001275833.1
• UniProt Accession #: Q24151; Q0KI43; Q24181; Q59DV7; Q5BIB0; Q8IN54; Q8SX55; Q9VDL8
• Molecular Weight: 86,415 Da
• NCBI Official Full Name: Signal-transducer and activator of transcription protein at 92E, isoform M
• NCBI Official Synonym Full Names: Signal-transducer and activator of transcription protein at 92E
• NCBI Official Symbol: Stat92E
• NCBI Official Synonym Symbols: CG4257; d-STAT; D-stat; D-Stat; D-STAT; D-stat/stat92E; DmelCG4257; DmSTAT; DRODSRC; DSRC; dstat; dSTAT; Dstat; DSTAT; Dstat 92E; dSTAT92E; Dstat92E; dSTAT92E/marelle; l(3)06346; l(3)j6C8; mrl; mrL; mrl stat92E; pSTAT; SD-stat; stat; Stat; STAT; STAT 92E;
• NCBI Protein Information: CG4257 gene product from transcript CG4257-RH; CG4257-PB; CG4257-PC; CG4257-PE; CG4257-PF; CG4257-PG; CG4257-PH; CG4257-PI; CG4257-PJ; CG4257-PK; CG4257-PL; CG4257-PM; Signal-transducer and activator of transcription protein; Signal-transducer and activator of transcription protein at 92E; Stat92E-PB; Stat92E-PC; Stat92E-PE; Stat92E-PF; Stat92E-PG; Stat92E-PH; Stat92E-PI; Stat92E-PJ; Stat92E-PK; Stat92E-PL; Stat92E-PM; marelle; signal transducer and activator of transcription; signal transducers and activator of transcription
• UniProt Protein Name: Signal transducer and transcription activator
• UniProt Gene Name: Stat92E
• UniProt Synonym Gene Names: MARE; mrL; Stat; d-STAT
• UniProt Entry Name: STAT_DROME

Uniprot Description

STAT5A: Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression. The Janus kinase-STAT pathway is connected to drosophila early development

Protein type: Oncoprotein; Transcription factor; Motility/polarity/chemotaxis; DNA-binding

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; signal transducer activity; DNA binding; transcription factor activity

Biological Process: oogenesis; negative regulation of Wnt receptor signaling pathway; lymph gland hemopoiesis; somatic stem cell maintenance; primary sex determination; stem cell division; compound eye development; defense response; signal transduction; negative regulation of antimicrobial humoral response; segment specification; regulation of JAK-STAT cascade; regulation of transcription, DNA-dependent; hemocyte proliferation; positive regulation of cell proliferation; somatic stem cell division; hemopoiesis; epithelial cell fate determination, open tracheal system; nervous system development; germ-line stem cell division; imaginal disc-derived wing morphogenesis; larval somatic muscle development; stem cell maintenance; oocyte localization during germarium-derived egg chamber formation; germ-line stem cell maintenance; ovarian follicle cell stalk formation; JAK-STAT cascade; humoral immune response; border follicle cell migration; sex determination; long-term memory; open tracheal system development; cell dedifferentiation; lamellocyte differentiation; hindgut morphogenesis; positive regulation of defense response to virus by host; eye-antennal disc morphogenesis; blastoderm segmentation