Rabbit anti-Human STARD13 Polyclonal Antibody | anti-STARD13 antibody

STARD13, ID (STARD13, DLC2, GT650, StAR-related lipid transfer protein 13, 46H23.2, Deleted in liver cancer 2 protein, Rho GTPase-activating protein, START domain-containing protein 13) (FITC)

Cat. Num. AAA6351755

• Gene Names: STARD13; DLC2; GT650; ARHGAP37; LINC00464
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: STARD13; Polyclonal Antibody; ID (STARD13; DLC2; GT650; StAR-related lipid transfer protein 13; 46H23.2; Deleted in liver cancer 2 protein; Rho GTPase-activating protein; START domain-containing protein 13) (FITC); START domain-containing protein 13; anti-STARD13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-STARD13 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: STARD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-573 amino acids from the Central region of human STARD13.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(STARD13 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the STARD13 antibody detected the STARD13 protein (arrow).)

Related Product Information for anti-STARD13 antibody

This gene encodes a protein that contains a sterile alpha motif domain in the N-terminus, an ATP/GTP-binding motif, a GTPase-activating protein domain, and a STAR-related lipid transfer domain in the C-terminus. The gene is located in a region of chromosome 13 that has loss of heterozygosity in hepatic cancer. At least three alternatively spliced transcript variants have been described for this gene.

Product Categories/Family for anti-STARD13 antibody

Antibodies; Cancer Markers

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Xiaorong, L., et al. BMC Cancer 8, 205 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 16445031
• NCBI GeneID: 90627
• NCBI Accession #: NP_443083.1; NP_821074.1; NP_821075.1
• NCBI GenBank Nucleotide #: NM_052851.2
• UniProt Accession #: Q9Y3M8; Q5HYH1; Q5TAE3; Q6UN61; Q86TP6; Q86WQ3; Q86XT1; A2A309; A2A310
• Molecular Weight: 76,367 Da
• NCBI Official Full Name: stAR-related lipid transfer protein 13 isoform 3
• NCBI Official Synonym Full Names: StAR related lipid transfer domain containing 13
• NCBI Official Symbol: STARD13
• NCBI Official Synonym Symbols: DLC2; GT650; ARHGAP37; LINC00464
• NCBI Protein Information: stAR-related lipid transfer protein 13
• UniProt Protein Name: StAR-related lipid transfer protein 13
• Protein Family: StAR-related lipid transfer protein
• UniProt Gene Name: STARD13
• UniProt Synonym Gene Names: DLC2; GT650; DLC-2; StARD13
• UniProt Entry Name: STA13_HUMAN

NCBI Description

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

STARD13: GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor; GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: mitochondrial membrane; lipid particle; cytosol

Molecular Function: protein binding; lipid binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity