Western Blot (WB)
(Western blotAll lanes: ST3GAL5 antibody at 6.2 ug/mlLane 1: K562 whole cell lysateLane 2: U251 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 48,46 kDaObserved band size: 48,60 kDa)
Rabbit anti-Human ST3GAL5 Polyclonal Antibody | anti-ST3GAL5 antibody
ST3GAL5 Antibody
Western Blot (WB)
(Western blotAll lanes: ST3GAL5 antibody at 6.2 ug/mlLane 1: K562 whole cell lysateLane 2: U251 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 48,46 kDaObserved band size: 48,60 kDa)
Western Blot (WB)
(Western blotAll lanes: ST3GAL5 antibody at 6.2 ug/mlLane 1: K562 whole cell lysateLane 2: U251 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 48,46 kDaObserved band size: 48,60 kDa)
NCBI and Uniprot Product Information
NCBI Description
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ST3GAL5: Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES). AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. Belongs to the glycosyltransferase 29 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; EC 2.4.99.9; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: Golgi membrane; integral to membrane; integral to plasma membrane
Molecular Function: beta-galactoside alpha-2,3-sialyltransferase activity; lactosylceramide alpha-2,3-sialyltransferase activity; neolactotetraosylceramide alpha-2,3-sialyltransferase activity; sialyltransferase activity
Biological Process: carbohydrate metabolic process; ganglioside biosynthetic process; glycosphingolipid biosynthetic process; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine
Disease: Amish Infantile Epilepsy Syndrome
Research Articles on ST3GAL5
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Product Notes
The ST3GAL5 st3gal5 (Catalog #AAA7045693) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ST3GAL5 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ST3GAL5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the ST3GAL5 st3gal5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ST3GAL5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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