Rabbit anti-Human, Mouse ST2 Polyclonal Antibody | anti-ST2 antibody

ST2 Antibody

Cat. Num. AAA9414783

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ST2; Polyclonal Antibody; ST2 Antibody; anti-ST2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 567

• Applicable Applications for anti-ST2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.
• Target Name: ST2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ST2 in mouse kidney lysate with ST2 antibody at 1 ug/mL in the presence (lane A) or absence (lane B) of 1 ug blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ST2 in mouse kidney tissue with ST2 antibody at 2 ug/mL.)

Related Product Information for anti-ST2 antibody

ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.

Product Categories/Family for anti-ST2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 286101
• Molecular Weight: 38,502 Da
• NCBI Official Full Name: ST2L protein
• UniProt Protein Name: Interleukin-1 receptor-like 1
• Protein Family: High affinity sulfate transporter
• UniProt Gene Name: Il1rl1
• UniProt Synonym Gene Names: Ly84; St2; Ste2
• UniProt Entry Name: ILRL1_MOUSE

Uniprot Description

IL1RL1: receptor for IL33. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of ERK1 and/or ERK2, p38-alpha, and JNK1. Apparently promotes the activation and differentiation of T-helper 2 cells. Belongs to the interleukin-1 receptor family. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Three isoforms of the human protein are produced by alternative splicing. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; membrane; integral to membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: interleukin-1 receptor activity

Biological Process: negative regulation of cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of interferon-gamma production; negative regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response