Mouse anti-Human SRGAP1 Polyclonal Antibody | anti-SRGAP1 antibody

SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1, srGAP1, Rho GTPase-activating Protein 13, ARHGAP13, KIAA1304)

Cat. Num. AAA6003632

• Gene Names: SRGAP1; ARHGAP13
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SRGAP1; Polyclonal Antibody; SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1; srGAP1; Rho GTPase-activating Protein 13; ARHGAP13; KIAA1304); Anti -SRGAP1 (SLIT-ROBO Rho GTPase-activating Protein 1; anti-SRGAP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SRGAP1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM

• Applicable Applications for anti-SRGAP1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence and Western Blot.; Dilution: Immunofluorescence: 10ug/ml
• Immunogen: Full length human SRGAP1, aa1-1085 (NP_065813.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SRGAP1 expression in transfected 293T cell line by SRGAP1 polyclonal antibody. Lane 1: SRGAP1 transfected lysate (119.35kD). Lane 2: Non-transfected lysate.)

Immunofluorescence (IF)

(Immunofluorescence of purified antibody to SRGAP1 on HeLa cell. [antibody concentration 10ug/ml].)

Product Categories/Family for anti-SRGAP1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 44917604
• NCBI GeneID: 57522
• NCBI Accession #: NP_065813.1
• NCBI GenBank Nucleotide #: NM_020762.2
• UniProt Accession #: Q7Z6B7; Q9H8A3; Q9P2P2
• Molecular Weight: 124,264 Da
• NCBI Official Full Name: SLIT-ROBO Rho GTPase-activating protein 1
• NCBI Official Synonym Full Names: SLIT-ROBO Rho GTPase activating protein 1
• NCBI Official Symbol: SRGAP1
• NCBI Official Synonym Symbols: ARHGAP13
• NCBI Protein Information: SLIT-ROBO Rho GTPase-activating protein 1; rho GTPase-activating protein 13
• UniProt Protein Name: SLIT-ROBO Rho GTPase-activating protein 1
• Protein Family: SLIT-ROBO Rho GTPase-activating protein
• UniProt Gene Name: SRGAP1
• UniProt Synonym Gene Names: ARHGAP13; KIAA1304; srGAP1
• UniProt Entry Name: SRGP1_HUMAN

Uniprot Description

ARHGAP13: GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 12q14.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; Rac GTPase binding

Biological Process: axon guidance; cell migration; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration; Rho protein signal transduction

Disease: Thyroid Carcinoma, Follicular