Rabbit anti-Human, Mouse SPTBN1 Polyclonal Antibody | anti-SPTBN1 antibody

SPTBN1-Specific Rabbit Polyclonal

Cat. Num. AAA7604437

• Gene Names: SPTBN1; ELF; SPTB2; HEL102; betaSpII
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SPTBN1; Polyclonal Antibody; SPTBN1-Specific Rabbit Polyclonal; anti-SPTBN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 2155

• Applicable Applications for anti-SPTBN1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Spectrin, beta, non-erythrocytic 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung using MBS7604437 (SPTBN1-Specific antibody) at dilution of 1:100)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7604437 (SPTBN1-Specific antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 112382252
• NCBI GeneID: 6711
• NCBI Accession #: NP_842565.2
• NCBI GenBank Nucleotide #: NM_178313.2
• Molecular Weight: 251,397 Da
• NCBI Official Full Name: spectrin beta chain, non-erythrocytic 1 isoform 2
• NCBI Official Synonym Full Names: spectrin beta, non-erythrocytic 1
• NCBI Official Symbol: SPTBN1
• NCBI Official Synonym Symbols: ELF; SPTB2; HEL102; betaSpII
• NCBI Protein Information: spectrin beta chain, non-erythrocytic 1
• UniProt Protein Name: Spectrin beta chain, non-erythrocytic 1
• Protein Family: Spectrin
• UniProt Gene Name: SPTBN1
• UniProt Synonym Gene Names: SPTB2
• UniProt Entry Name: SPTB2_HUMAN

NCBI Description

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SPTBN1: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: axolemma; cell-cell adherens junction; cytoplasm; cytosol; nucleolus

Molecular Function: ankyrin binding; GTPase binding; protein binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton

Biological Process: axon guidance; cytokinesis after mitosis; ER to Golgi vesicle-mediated transport; Golgi to plasma membrane protein transport; MAPKKK cascade; plasma membrane organization and biogenesis