Rabbit anti-Mouse Sprouty 1 Polyclonal Antibody | anti-SPRY1 antibody
Sprouty 1 (Spry 1)
Gene Names
SPRY1; hSPRY1
Reactivity
Mouse
Applications
Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Sprouty 1; Polyclonal Antibody; Sprouty 1 (Spry 1); Anti -Sprouty 1 (Spry 1); anti-SPRY1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Specificity
Recognizes mouse Sprouty-1 at ~34kD. A band of unknown origin was observed at ~120kD. Reactivity has been confirmed with two day-old mouse kidney homogenates. Does not recognize rat Sprouty-1.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.1% sodium azide.
Applicable Applications for anti-SPRY1 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1-3ug/ml
Optimal dilution to be determined by the researcher.
Dilution: Western Blot: 1-3ug/ml
Optimal dilution to be determined by the researcher.
Immunogen
Synthetic peptide derived from the N-terminal region of mouse and rat Sprouty-1
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-SPRY1 antibody
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor- and vascular endothelial growth factor-induced proliferation and differentiation by repressing
Product Categories/Family for anti-SPRY1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
35,122 Da
NCBI Official Full Name
sprouty 1
NCBI Official Synonym Full Names
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
NCBI Official Symbol
SPRY1
NCBI Official Synonym Symbols
hSPRY1
NCBI Protein Information
protein sprouty homolog 1; spry-1; OTTHUMP00000164086; OTTHUMP00000219789; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
UniProt Protein Name
Protein sprouty homolog 1
Protein Family
UniProt Gene Name
SPRY1
UniProt Entry Name
SPY1_HUMAN
Uniprot Description
SPRY1: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Induced by FGF signaling.
Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of MAP kinase activity; establishment of mitotic spindle orientation; ureteric bud development; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of nerve growth factor receptor signaling pathway; induction of an organ; negative regulation of Ras protein signal transduction; metanephros development
Research Articles on SPRY1
Similar Products
Product Notes
The SPRY1 spry1 (Catalog #AAA622928) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sprouty 1 (Spry 1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Sprouty 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1-3ug/ml Optimal dilution to be determined by the researcher. Researchers should empirically determine the suitability of the SPRY1 spry1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sprouty 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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