Western Blot (WB)
(SPNXB Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SPNXB antibody detected the SPNXB protein (arrow).)
Rabbit anti-Human SPNXB Polyclonal Antibody | anti-SPANXB1 antibody
SPNXB Antibody (Center)
Western Blot (WB)
(SPNXB Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SPNXB antibody detected the SPNXB protein (arrow).)
Western Blot (WB)
(SPNXB Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SPNXB antibody detected the SPNXB protein (arrow).)
several testis-specific genes is required to initiate the series of
molecular and morphological changes in the male germ cell lineage
necessary for the formation of mature spermatozoa. This gene is a
member of the SPANX family of cancer/testis-associated genes, which
are located in a cluster on chromosome X. The SPANX genes encode
differentially expressed testis-specific proteins that localize to
various subcellular compartments. This particular gene maps to
chromosome X in a head-to-tail orientation with SPANX family member
B1 and appears to be a duplication of that locus. The SPANXB genes
are unique members of this gene family, since they contain an
additional 18 nt in their coding region compared to the majority of
family members. Although the protein encoded by this gene contains
consensus nuclear localization signals, the major site for
subcellular localization of expressed protein is in the cytoplasmic
droplets of ejaculated spermatozoa. This protein provides a
biochemical marker for studying the unique structures in
spermatazoa, while attempting to further define its role in
spermatogenesis.
Hansen, M.A., et al. Mol. Reprod. Dev. 75(2):219-229(2008)
Kouprina, N., et al. Genome Res. 15(11):1477-1486(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Zendman, A.J., et al. Gene 309(2):125-133(2003)
NCBI and Uniprot Product Information
NCBI Description
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]
Uniprot Description
SPANXB1: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: Xq27.1
Cellular Component: cytoplasm; nucleus
Biological Process: spermatid development
Research Articles on SPANXB1
Similar Products
Product Notes
The SPANXB1 spanxb1 (Catalog #AAA9206014) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 17-47. The SPNXB Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPNXB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SPANXB1 spanxb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPNXB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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