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Rabbit anti-Human, Mouse SPNS2 Polyclonal Antibody | anti-SPNS2 antibody

SPNS2 Antibody

Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SPNS2; Polyclonal Antibody; SPNS2 Antibody; Protein spinster homolog 2; Spinster homolog 2 (Drosophila); spinster homolog 2; SPNS 2; SPNS2 protein; anti-SPNS2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SPNS2 Antibody detects endogenous levels of SPNS2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SPNS2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SPNS2.
Conjugation
Unconjugated
Similarity
Belongs to the major facilitator superfamily. Spinster (TC 2. A. 1. 49) family.
Function
Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function. S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SPNS2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
58,044 Da
NCBI Official Full Name
SPNS2 protein
NCBI Official Synonym Full Names
sphingolipid transporter 2
NCBI Official Symbol
SPNS2
NCBI Protein Information
protein spinster homolog 2
UniProt Protein Name
Protein spinster homolog 2
Protein Family
UniProt Gene Name
SPNS2
UniProt Entry Name
SPNS2_HUMAN

Uniprot Description

SPNS2: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; lysosomal membrane; vesicle

Molecular Function: sphingolipid transporter activity

Biological Process: B cell homeostasis; lipid transport; locomotion; lymph node development; regulation of eye pigmentation; regulation of humoral immune response; sphingolipid metabolic process; T cell homeostasis; transmembrane transport

Research Articles on SPNS2

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Product Notes

The SPNS2 spns2 (Catalog #AAA9631132) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPNS2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SPNS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SPNS2 spns2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPNS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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