Rabbit anti-Human, Mouse SPATA7 Polyclonal Antibody | anti-SPATA7 antibody

SPATA7 Rabbit Polyclonal

Cat. Num. AAA7604398

• Gene Names: SPATA7; HSD3; LCA3; HSD-3.1; HEL-S-296
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SPATA7; Polyclonal Antibody; SPATA7 Rabbit Polyclonal; anti-SPATA7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 567

• Applicable Applications for anti-SPATA7 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Immunogen: Spermatogenesis associated 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7604398 (SPATA7 Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7604398 (SPATA7 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 94536850
• NCBI GeneID: 55812
• NCBI Accession #: NP_001035518.1
• NCBI GenBank Nucleotide #: NM_001040428.3
• Molecular Weight: 51,931 Da
• NCBI Official Full Name: spermatogenesis-associated protein 7 isoform 2
• NCBI Official Synonym Full Names: spermatogenesis associated 7
• NCBI Official Symbol: SPATA7
• NCBI Official Synonym Symbols: HSD3; LCA3; HSD-3.1; HEL-S-296
• NCBI Protein Information: spermatogenesis-associated protein 7
• UniProt Protein Name: Spermatogenesis-associated protein 7
• Protein Family: Spermatogenesis-associated protein
• UniProt Gene Name: SPATA7
• UniProt Synonym Gene Names: HSD3
• UniProt Entry Name: SPAT7_HUMAN

NCBI Description

This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

SPATA7: May be involved in retinal function. Defects in SPATA7 are the cause of Leber congenital amaurosis type 3 (LCA3). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in SPATA7 are a cause of retinitis pigmentosa autosomal recessive (ARRP). ARRP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: axoneme; cytoplasm; microtubule cytoskeleton; photoreceptor connecting cilium

Molecular Function: protein binding

Biological Process: photoreceptor cell maintenance; response to stimulus; spermatogenesis; visual perception

Disease: Leber Congenital Amaurosis 3