Rabbit anti-Human SPANXD Polyclonal Antibody | anti-SPANXD antibody

SPANXD Antibody

Cat. Num. AAA7050715

• Gene Names: SPANXD; CT11.4; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: SPANXD; Polyclonal Antibody; SPANXD Antibody; Sperm protein associated with the nucleus on the X chromosome D; Cancer/testis antigen 11.4; Nuclear-associated protein SPAN-Xd; SPANX-D; SPANX family member D; SPANX; anti-SPANXD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Liquid
• Sequence Length: 97

• Applicable Applications for anti-SPANXD antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-1: 200
• Immunogen: Recombinant human Sperm protein associated with the nucleus on the X chromosome D protein (1-97AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis using MBS7050715 at dilution 1:100)

References

[1]"Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27."Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W., Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J., Larionov V.Genome Res. 15: 1477-1486(2005). [2]"The DNA sequence of the human X chromosome."Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434: 325-337(2005). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14: 2121-2127(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 14192939
• NCBI GeneID: 64648
• NCBI Accession #: NP_115793.1
• NCBI GenBank Nucleotide #: NM_032417.3
• UniProt Accession #: Q9BXN6; Q5JWI1
• Molecular Weight: 11,029 Da
• NCBI Official Full Name: sperm protein associated with the nucleus on the X chromosome D
• NCBI Official Synonym Full Names: SPANX family member D
• NCBI Official Symbol: SPANXD
• NCBI Official Synonym Symbols: CT11.4; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1
• NCBI Protein Information: sperm protein associated with the nucleus on the X chromosome D
• UniProt Protein Name: Sperm protein associated with the nucleus on the X chromosome D
• Protein Family: Sperm protein associated with the nucleus on the X chromosome
• UniProt Gene Name: SPANXD
• UniProt Synonym Gene Names: CT11.4; SPANX-D
• UniProt Entry Name: SPNXD_HUMAN

NCBI Description

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate cancer susceptibility. [provided by RefSeq, Apr 2014]

Uniprot Description

SPANXD: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. [provided by RefSeq, Jul 2008]

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq27.1

Cellular Component: nucleus

Molecular Function: protein binding