Immunohistochemistry (IHC)
(Rabbit Anti-SP 140 AntibodyParaffin Embedded Tissue: Human KidneyCellular Data: Epithelial cells of renal tubuleAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Rabbit SP140 Polyclonal Antibody | anti-SP140 antibody
SP140 antibody - N-terminal region
Predicted Species Reactivity: Dog, Horse, Human, Mouse, Pig, Rat
Predicted Species Reactivity: Dog, Horse, Human, Mouse, Pig, Rat
Immunohistochemistry (IHC)
(Rabbit Anti-SP 140 AntibodyParaffin Embedded Tissue: Human KidneyCellular Data: Epithelial cells of renal tubuleAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Immunohistochemistry (IHC)
(Rabbit Anti-SP 140 AntibodyParaffin Embedded Tissue: Human KidneyCellular Data: Epithelial cells of renal tubuleAntibody Concentration: 4.0-8.0 ug/mlMagnification: 400X)
Western Blot (WB)
(Host: RabbitTarget Name: SP140Sample Type: Human Lung TumorAntibody Dilution: 0.5 ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: SP140Sample Type: Human Lung TumorAntibody Dilution: 0.5 ug/ml)
Western Blot (WB)
(WB Suggested Anti-SP140 Antibody Titration: 5.0ug/mlPositive Control: Raji cell lysateSP140 is supported by BioGPS gene expression data to be expressed in Raji)
Western Blot (WB)
(WB Suggested Anti-SP140 Antibody Titration: 5.0ug/mlPositive Control: Raji cell lysateSP140 is supported by BioGPS gene expression data to be expressed in Raji)
Target Description: SP140 is the nuclear body protein found specifically in all NP cells. HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Uniprot Description
SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity
Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response
Research Articles on SP140
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Product Notes
The SP140 sp140 (Catalog #AAA3201205) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SP140 antibody - N-terminal region reacts with Tested Species Reactivity: Human Predicted Species Reactivity: Dog, Horse, Human, Mouse, Pig, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SP140 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the SP140 sp140 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: PEPIFRFFRE NKVEIASAIT RPFPFLMGLR DRSFISEQMY EHFQEAFRNL. It is sometimes possible for the material contained within the vial of "SP140, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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