Rabbit SOX6 Polyclonal Antibody | anti-SOX6 antibody

SOX6 Polyclonal Antibody

Cat. Num. AAA194433

• Gene Names: SOX6; SOXD; HSSOX6
• Applications: Immunoblot, Western Blot
• Synonyms: SOX6; Polyclonal Antibody; SOX6 Polyclonal Antibody; anti-SOX6 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: SOX6 [Rabbit polyclonal antibody to SOX6]; This antibody recognizes human SOX6 and is predicted to recognize mouse, rat, and chimpanzee SOX6 based on 100% sequence homology.
• Form/Format: 100 ug Protein G-purified antibody in PBS, pH 7.4.

• Applicable Applications for anti-SOX6 antibody: Immunoblot
• Application Notes: Immunoblotting : use at 1-5ug/ml. A band of approximately 93 kDa is detected. These are recommended concentrations. User should determine optimal concentrations for their applications.
• Immunogen: Synthetic peptide corresponding to amino acids 780-796 of human and mouse SOX6.
• Preservatives: None. Available on request.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Related Product Information for anti-SOX6 antibody

The SOX gene family is defined by the Sry-related HMG box domain that mediates sequence-specific DNA binding. A variety of functions are associated with the SOX proteins during development. SOX6 is believed to regulate embryonic development and determine cell fate. Mouse SOX6 is expressed in the CNS during embryogenesis, but this expression decreases significantly in the adult CNS. In humans, SOX6 is expressed in fetal brain and in gliomas but only at very low levels in the adult brain. A direct link between SOX6 expression and malignancy has not been demonstrated, so SOX6 probably does not promote proliferation, but it may induce transformation activity in the early stage of oncogenesis in gliomas.

Product Categories/Family for anti-SOX6 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 13442973
• NCBI GeneID: 55553
• UniProt Accession #: P35712; Q86VX7; Q9BXQ3; Q9BXQ4; Q9BXQ5; Q9H0I8
• Molecular Weight: 91,921 Da
• NCBI Official Full Name: SOX6
• NCBI Official Synonym Full Names: SRY (sex determining region Y)-box 6
• NCBI Official Symbol: SOX6
• NCBI Official Synonym Symbols: SOXD; HSSOX6
• NCBI Protein Information: transcription factor SOX-6; OTTHUMP00000231372; OTTHUMP00000231373; OTTHUMP00000231374; OTTHUMP00000231375; SRY-box containing gene 6
• UniProt Protein Name: Transcription factor SOX-6
• Protein Family: Transcription factor
• UniProt Gene Name: SOX6
• UniProt Entry Name: SOX6_HUMAN

NCBI Description

This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.

Uniprot Description

SOX6: Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: muscle development; erythrocyte development; transcription, DNA-dependent; in utero embryonic development; cell morphogenesis; gene silencing; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte cell fate specification; cardiac muscle cell differentiation; post-embryonic development; positive regulation of chondrocyte differentiation; astrocyte differentiation; regulation of transcription, DNA-dependent; cartilage development; positive regulation of transcription from RNA polymerase II promoter