Testing Data
(Image: Labeling for SOX6 in the notochord of 12 d.p.c. mouse embryos. Detection was done using anti-rabbit-Cy3 conjugated secondary antibodies (red fluorescence). Cell nuceli were counterstained with DAPI (blue fluorescence). Mounted with i-BRITE Plus)
SOX6 Antibody | anti-SOX6 antibody
SOX6, Affinity Purified Antibody, Rabbit
Testing Data
(Image: Labeling for SOX6 in the notochord of 12 d.p.c. mouse embryos. Detection was done using anti-rabbit-Cy3 conjugated secondary antibodies (red fluorescence). Cell nuceli were counterstained with DAPI (blue fluorescence). Mounted with i-BRITE Plus)
Testing Data
(Image: Labeling for SOX6 in the notochord of 12 d.p.c. mouse embryos. Detection was done using anti-rabbit-Cy3 conjugated secondary antibodies (red fluorescence). Cell nuceli were counterstained with DAPI (blue fluorescence). Mounted with i-BRITE Plus)
SOX6 is a transcriptional factor that is specifically expressed in the developing central nervous system and in the early stages of chondrogenesis in mouse embryos. Results indicate that the developmentally regulated transcription factor SOX6 is aberrantly expressed in glioma.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Description
SOX6: Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 11p15.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: erythrocyte development; muscle development; transcription, DNA-dependent; in utero embryonic development; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; gene silencing; oligodendrocyte cell fate specification; cardiac muscle cell differentiation; post-embryonic development; positive regulation of chondrocyte differentiation; regulation of transcription, DNA-dependent; astrocyte differentiation; cartilage development; positive regulation of transcription from RNA polymerase II promoter
Research Articles on SOX6
Similar Products
Product Notes
The SOX6 sox6 (Catalog #AAA555256) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The SOX6, Affinity Purified Antibody, Rabbit reacts with Human, Mouse, Primate, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SOX6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the SOX6 sox6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOX6, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
