Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Rat Lung Tissue )
Rabbit SOX2 Polyclonal Antibody | anti-SOX2 antibody
Anti-SOX2 antibody
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Rat Lung Tissue )
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Rat Lung Tissue )
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-SOX2 antibody, MBS177048, IHC(P)IHC(P): Human Lung Cancer Tissue )
Western Blot (WB)
(Anti-SOX2 antibody, MBS177048, All Western blottingAll lanes: Anti-SOX2(MBS177048) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugLane 2: Mouse Brain Tissue Lysate at 40ugPredicted bind size: 34KDObserved bind size: 34KD)
Western Blot (WB)
(Anti-SOX2 antibody, MBS177048, All Western blottingAll lanes: Anti-SOX2(MBS177048) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugLane 2: Mouse Brain Tissue Lysate at 40ugPredicted bind size: 34KDObserved bind size: 34KD)
Background: SRY(sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency of undifferentiated embryonic stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This gene is mapped to 3q26.33. It is found that SOX2 can regulate OCT3/4 expression and maintains ES pluripotency through upstream transcription factors. SOX2 is identified as a lineage-survival oncogene in lung and esophageal squamous cell carcinoma. In addition to those, SOX2 has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.
NCBI and Uniprot Product Information
NCBI Description
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Uniprot Description
SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3q26.3-q27
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; miRNA binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; tongue development; establishment and/or maintenance of chromatin architecture; somatic stem cell maintenance; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; diencephalon morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; olfactory placode formation; forebrain neuron differentiation; detection of mechanical stimulus involved in equilibrioception; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; tissue regeneration; forebrain development; male genitalia development; positive regulation of cell-cell adhesion; response to wounding; adenohypophysis development; positive regulation of epithelial cell differentiation; negative regulation of osteoblast differentiation; cell cycle arrest; inner ear development; positive regulation of Notch signaling pathway; negative regulation of epithelial cell proliferation; positive regulation of neuroblast proliferation; inner ear morphogenesis; response to retinoic acid; neuron fate commitment; detection of mechanical stimulus involved in sensory perception of sound; osteoblast differentiation; negative regulation of neuron differentiation; eye development; regulation of gene expression; pituitary gland development; glial cell fate commitment; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; pigment biosynthetic process; alveolus development; retina morphogenesis in camera-type eye
Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on SOX2
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Product Notes
The SOX2 sox2 (Catalog #AAA177048) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SOX2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SOX2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the SOX2 sox2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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