Rabbit anti-Human Sorting Nexin 9 (SNX9) Polyclonal Antibody | anti-SNX9 antibody

HRP-Linked Polyclonal Antibody to Sorting Nexin 9 (SNX9)

Cat. Num. AAA2075700

• Gene Names: SNX9; SDP1; WISP; SH3PX1; SH3PXD3A
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Synonyms: Sorting Nexin 9 (SNX9); Polyclonal Antibody; HRP-Linked Polyclonal Antibody to Sorting Nexin 9 (SNX9); SDP1; SH3PX1; SH3PXD3A; WISP; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; anti-SNX9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Concentration: 500ug/ml (varies by lot)

• Applicable Applications for anti-SNX9 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
• Immunogen: SNX9 (Phe250~Met595)
• Conjugation: HRP
• Cross Reactivity: Human
• Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2027262

NCBI and Uniprot Product Information

• NCBI GI #: 4689258
• NCBI GeneID: 51429
• Molecular Weight: 66,592 Da
• NCBI Official Full Name: sorting nexin 9
• NCBI Official Synonym Full Names: sorting nexin 9
• NCBI Official Symbol: SNX9
• NCBI Official Synonym Symbols: SDP1; WISP; SH3PX1; SH3PXD3A
• NCBI Protein Information: sorting nexin-9
• UniProt Protein Name: Sorting nexin-9
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX9
• UniProt Synonym Gene Names: SH3PX1; SH3PXD3A; Protein SDP1

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]

Uniprot Description

SNX9: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cell-cell adherens junction; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; endosome; extrinsic to internal side of plasma membrane; plasma membrane; trans-Golgi network

Molecular Function: phosphatidylinositol binding; phosphoinositide binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding

Biological Process: cytokinesis after mitosis; endocytosis; endosome transport; intracellular protein transport; positive regulation of GTPase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase activity; positive regulation of protein oligomerization; receptor-mediated endocytosis; vesicle organization and biogenesis