Rabbit anti-Mouse, Rat Somatostatin Receptor Type 3 (SSTR3) Polyclonal Antibody | anti-SSTR3 antibody

Anti-Somatostatin Receptor Type 3 (SSTR3) Antibody

Cat. Num. AAA4157644

• Gene Names: SSTR3; SS3R; SS3-R; SS-3-R; SSR-28
• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Somatostatin Receptor Type 3 (SSTR3); Polyclonal Antibody; Anti-Somatostatin Receptor Type 3 (SSTR3) Antibody; anti-SSTR3 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 418

• Applicable Applications for anti-SSTR3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Peptide KVRSTTRRVRAPSC corresponding to residues 233-246 of rat SSTR3 (Accession# P30936).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-SSTR3 antibody

Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. SST induces in target cells a variety of physiological functions that include nueromodulation, cell secretion, cell proliferation and smooth muscle contractility. SST acts on its multiple cell targets via a family of six receptors that are originated form five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation. SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. Thus, SSTR3 expression in the brain is primarily concentrated in the cerebellum with lesser expression in peripheral organs such as the spleen, the liver and the pituitary. Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain. We have now developed a new antibody against a highly conserved epitope in the third intracellular loop of the rat SSTR3. The antibody will also recognize mouse samples.

NCBI and Uniprot Product Information

• NCBI GI #: 4557861
• NCBI GeneID: 6753
• NCBI GenBank Nucleotide #: NP_001042.1
• UniProt Accession #: P32745
• NCBI Official Full Name: somatostatin receptor type 3
• NCBI Official Synonym Full Names: somatostatin receptor 3
• NCBI Official Symbol: SSTR3
• NCBI Official Synonym Symbols: SS3R; SS3-R; SS-3-R; SSR-28
• NCBI Protein Information: somatostatin receptor type 3
• UniProt Protein Name: Somatostatin receptor type 3
• Protein Family: Somatostatin receptor
• UniProt Gene Name: SSTR3
• UniProt Synonym Gene Names: SS-3-R; SS3-R; SS3R
• UniProt Entry Name: SSR3_HUMAN

NCBI Description

This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SSTR3: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: neuron projection; nonmotile primary cilium; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide binding; somatostatin receptor activity; protein binding

Biological Process: response to starvation; synaptic transmission; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; neuropeptide signaling pathway; induction of apoptosis by hormones; organelle organization and biogenesis; forebrain development; cerebellum development; spermatogenesis; regulation of insulin secretion