Testing Data
(Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE SOCS5 antibody diluted at 1: 1000)
Rabbit anti-Human SOCS5 Polyclonal Antibody | anti-SOCS5 antibody
SOCS5 antibody
Immunohistochemistry: 1:100-1:250
Testing Data
(Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE SOCS5 antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE SOCS5 antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Ca922 xenograft, using SOCS5 antibody at 1: 100 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Ca922 xenograft, using SOCS5 antibody at 1: 100 dilution.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: cytoplasm
Molecular Function: protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; epidermal growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of T-helper 2 cell differentiation; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; protein ubiquitination; cell growth; positive regulation of T-helper 1 cell differentiation; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of signal transduction
Research Articles on SOCS5
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Product Notes
The SOCS5 socs5 (Catalog #AAA9408514) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SOCS5 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SOCS5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:250. Researchers should empirically determine the suitability of the SOCS5 socs5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOCS5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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